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《Traditional Chinese Drug Research and Clinical Pharmacology》 2011-04
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Stability of Bajijiasu in Simulated Conditions of Human Stomach and Intestines

CH EN Yonggang 1,LIN Li 2,WU Jinhu 1,CHEN Diling 2,ZHUANG Manxian 2 (1.The Third Hospital of Wuhan,Wuhan 430060 Hubei,China;2.School of Chinese Materia Medica,Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China)  
Objective To investigate the stability of Bajijiasu in simulated conditions of human stomach and in-stestines,which will provide evidence for the design of oral form design.Methods We examined the stability of Baji-jiasu in the dilute hydrochloric acid solution for 2 hours,in artificial gastric juice for 2 hours,in buffer phosphate(pH being 6.8)for 12 hours and in artificial intestinal juice for 12 hours with HPLC-ELSD.Results The content of Bajijiasu remained 67.59 % in dilute hydrochloric acid solution and remained 64.85 % in artificial gastric juice after incubation for 30 minutes,and decreased to 43.31 % and 50.41 %,respectively after incubation for 120 minutes.Af-ter incubation for 12 hours in buffer phosphate(pH being 6.8)and in artificial intestinal juice,the content of Bajijia-su remained 90.43 % and 90.65 %,respectively.Conclusion It is indicated that Bajijiasu is unstable in dilute hy-drochloric acid solution and in artificial gastric juice,but stable in buffer phosphate(pH being 6.8)and in artificial intestinal juice.So the effect of human body gastric juice should be taken into account for the design of oral form of Bajijiasu.
【Fund】: 海南省重点科技项目(090603)
【CateGory Index】: R284;R283
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