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《Traditional Chinese Drug Research and Clinical Pharmacology》 2012-01
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In-vivo Intestinal Absorption Mechanism Study for Polysaccharides of Morindae ficinalis

CHEN Diling,CHEN Zhenxing,LIN Li,CHEN Kang,ZHANG Peng,LIANG Xing,LIANG Zheyu,ZHANG Yu,WU Junsheng(School of Chinese Materia Medica,Guangzhou University of Chinese Medicine,Guangzhou 510006,China)  
Objective To investigate the absorption kinetics of polysaccharides of Morindae ficinalis in rat small intestines,to observe the effects of absorption enhancers and pH value on the absorptive kinetics,and to explore the intestinal absorption mechanism of the polysaccharides.Methods Ultra-violet(UV)spectrophotometry was used to determine the content of phenol red.After coloration with developing reagents of phenol and vitriol,the polysaccharides were determined with UV spectrophotometry.An in-situ intestinal absorptive model was employed to investigate the absorption of polysaccharides in rat small intestines.Results There was no difference between the Ka of various concentrations of the polysaccharides.But the absorption percentage was effected by pH value and absorption enhancers.The absorption percentage was 57.25 ±1.28% when pH value was at 7.4,44.40±2.01% when pH at 6.8,and 42.94±2.15% when pH at 5.0,the difference being significant between them(P 0.01).With 0.5% sodium dodecyl sulfate added,the absorption was 59.21±1.49%,and with 0.5%Tween-80 added,the percentage was 53.18±2.59%,the difference being significant(P 0.01).Conclusion The polysaccharides are absorbed by passive diffusion mechanism.The absorption percentage is higher at pH 7.4 and enhanced by both of sodium dodecyl sulfate and Tween-80,and the effect of the sodium dodecyl sulfate is better.
【Fund】: 海南省科技重点项目(090603);; 广东省科技计划项目(2011B031700062);; 2011年省级大学生实验创新项目(1057211018)
【CateGory Index】: R285.5
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