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《Traditional Chinese Drug Research and Clinical Pharmacology》 2013-03
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Influence of Compound Chenxiang Gastric Tablets on Gastric Mucosal Pathomorphology of Rats with Chronic Gastritis

GUO Yuxin1,YANG Peng2,ZHANG Sanyin1,CHEN Jin(31.Chengdu University of Traditional Chinese Medicine,Chengdu 611137 Sichuan,China;2.Chengdu Fifth People's Hospital,Chengdu 611130 Sichuan,China;3.Haoyisheng Panxi Medicinal Co.Ltd,Chengdu 610000 Sichuan,China)  
Objective To observe the influence of Compound Chenxiang gastric tablets on gastric mucosal pathomorphology of rats with chronic gastritis,and to explore its protective effect on gastric mucosa.Methods Eighty rats were randomly divided into normal control group,model group,Compound Chenxiang gastric tablets group,hydrotalcite group and Sanjiu Weitai group,16 rats in each group.Except for normal control group,rats in the other groups were given sodium deoxycholate,40 % alcohol and indomethacin to establish the model of chronic gastritis.After the establishment of model,the rats were administered the corresponding drugs according to the experimental design for one continuous month,and then the gastric tissue was sampled for the observation of pathological morphological changes.Results Compared with the model group,gastric mucosal inflammation was relieved apparently,and the score of inflammation was decreased in Compound Chenxiang gastric tablets group and Sanjiu Weitai group after treatment,the difference being statistically significant(P 0.01).And the decrease in Compound Chenxiang gastric tablets group was superior to that in Sanjiu Weitai group.Conclusion Compound Chenxiang gastric tablets can alleviate the gastric mucosal inflammation reaction in chronic gastritis rats,thus play a role in protecting gastric mucosa.
【CateGory Index】: R285.5
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