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《Traditional Chinese Drug Research and Clinical Pharmacology》 2014-03
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Effect of Compound Rhizoma Polygoni Cuspidati Extract on Blood Lipid Levels and Atherogenic Index in Hyperlipidemia Model Rats

LI Bo;LI Xiongying;LV Guiyuan;SU Jie;ZHAO Yan;HU Xiu;LOU Jinying;CHEN Suhong;Wenzhou Medical University;Zhejiang Chinese Medical University;The Fifth Hospital of Jinhua;  
Objective To research the effects of compound Rhizoma Polygoni Cuspidati extract(CRPCE)on body weight,blood lipid levels and atherogenic index of rats with hyperlipidemia induced by high-fat diet. Methods SD rats were fed with high-fat diet for 11 weeks to establish hyperlipidemic model. Body weight was examined before and after modeling. The modeled rats were given intragastric infusion of CRPCE at the dosage of 4,8,12 g·kg-1respectively for 8 continuous weeks. The blood of rats was sampled on medication week 2,4,6 and 8,and then the serum levels of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-c)and low density lipoprotein cholesterol(HDL-c) as well as atherosclerosis index(AI)were measured. Results Compared with the model group,CRPCE showed the hyperlipidemic effect after oral administration for 4 weeks:except for AI in the low-dosage CRPCE group,the contents of TC,TG,LDL-c and AI were decreased all of CRPCE groups(P 0.01,P 0.05). On medication week 8,TC,LDL-c and AI were decreased in low- and middle-dosage CRPCE groups(P 0.01,P 0.05),HDL-c was increased in middle- and high-dosage CRPCE group(P 0.05),and AI was decreased in high-dosage CRPCE group(P 0.01). Conclusion CRPCE at the dosage of 4,8,12 g·kg-1has hypolipidemic effect on improving serum lipid levels of rats with hyperlipidemia induced by high-fat diet,and CRPCEat the dosage of 8,12 g·kg-1has better hypolipidemic effect.
【Fund】: 国家重大新药创制专项(2011ZX09102-011-07);; 金华市科技计划项目(2011-3-070)
【CateGory Index】: R285.5;R-332
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