Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Traditional Chinese Drug Research and Clinical Pharmacology》 2019-12
Add to Favorite Get Latest Update

The Active Mechanism of Astragali Radix-Curcumae Rhizoma Herb Pair on Gastric Precancerous Lesions Based on Network Pharmacology

LI Jiali;YANG Zehong;YANG Liangjun;LI Siyi;LIU Wei;LIU Yang;PAN Huafeng;Science and Technology Innovation Center,Guangzhou University of Chinese Medicine;  
Objective To investigate the active ingredients and mechanisms of Astragali radix-Curcumae rhizoma herb pair in treating gastric precancerous lesions(GPL)based on the network pharmacology. Methods The main active ingredients of Astragali radix-Curcumae rhizoma herb pair were obtained by the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)website with the criteria based on oral bioavailability(OB)≥30%, drug-like(DL)≥0.18, combined with related literatures. The corresponding targets of the active ingredients were screened by the TCMSP and Swiss Target Prediction,and the UniProt database was used to query the human gene corresponding to each target protein. The targets of GPL were collected by Genecards database,mapped to the target genes of the active ingredients of Astragali radix-Curcumae rhizoma herb pair,and the active components-target network were constructed. Interactive protein-protein interaction network(PPI)was constructed by STRING website. The common target genes were subjected to gene ontology(GO)enrichment and Kyoto encyclopedia of genes and genomes(KEGG)pathway enrichment analyses by Enricher database. The target-pathway network was constructed using Cytoscape 3.6.1 software. Results 166 compounds,28 active components and 112 common target genes of Astragali radix-Curcumae rhizoma herb pair were obtained,as well as 26 key genes with a value of ≥30 in the PPI network were selected. There were 45 GO terms related to biological process in GO enrichment analysis.Enrichment analysis revealed that, there were 18 KEGG pathways, including pathways in cancer, PI3 K-Akt signaling pathway, p53 signaling pathway, etc. Conclusion Astragali radix-Curcumae rhizoma herb pair may involve in various physiological processes such as tumor cell proliferation and apoptosis to exert an intervention effect on GPL by multiple components,multiple targets and multiple pathways.
【Fund】: 广东省普通高校特色创新类项目(2018KTSCX040);; 广东省自然科学基金项目(2017A030313845);; 广州市科技计划项目(201803010055);; 国家自然科学基金项目(81673946)
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 5 Hits
1 JIAO Jian-peng;KANG Ning;WEI Pin-kang;LI Yong-jin;SUN Da-zhi;The Second Affiliated Hospital of The Second Military Medical University;China Association of Chinese Medicine;;Treatment of precancerous lesions of gastric cancer frcm phlegm[J];中华中医药杂志;2014-05
2 CHEN Jing,ZHAO Aiguang,CAO Nida,ZHU Xiaohong(Department of Oncology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China);Advances in Research of Spleen Deficiency in Gastric Precancerous Conditions,Precancerous Lesions of Gastric cancer and Gastric Cancer[J];中华中医药学刊;2013-07
3 LIU Li REN Yuan LI Haowen GUO Ancheng WANG Yajie▲ The Clinical Research Center,Beijing Tiantan Hospital Affiliated to Capital Medical University,Beijing 010010,China;Inhibitory effects of Astragalosides on the glioblastom cell line SHG44 and its machanisms[J];中国医药导报;2013-03
4 Yao-Fu Fan,Mu-Xin Wei,Department of Chinese Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China;Precancerous lesions of gastric cancer:Research progress and preventive strategies[J];世界华人消化杂志;2012-20
5 WEI Jin-wen,FAN Yu,ZHANG You-li,WU Ying(Affiliated Hospital of Jiangsu University,Zhenjiang 212001,P.R.China);Effects of Quercetin on telomerase activity and apoptosis in gastric cancer cells[J];山东医药;2007-35
Chinese Journal Full-text Database 10 Hits
1 XIE Jingri;SUN Tao;ZHANG Yang;LI Hewei;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine;Heilongjiang University of Chinese Medicine;;Research Progress of Gastric Precancerous Lesions in TCM and Analysis on Related Problems[J];中华中医药学刊;2015-07
2 JIA Xue-feng;CHEN Wen-ming;SUN Dao-ping;ZHAO Hai-bo;JIANG Shu-long;LIU Ning;YANG Fan;Oncology Department,the First People's Hospital of Jining;School of Basic Medicine,Xiang'nan University;;Quercetin in inhibiting the epithelial-mesenchymal transition of gastric cancer[J];海南医学院学报;2015-08
3 ZHU Xuanxuan;ZHANG Xuefei;LIU Shenlin;Nanjing University of Chinese Medicine;Affiliated Hospital of Nanjing University of Chinese Medicine;;Study of the Effect of Weiliuan of Different Prescriptions on Gastrointetinal Regulation Factor in Spleen- deficiency Rats[J];中华中医药学刊;2015-05
4 HU Junyuan;LIU Qiao;WANG Jian;YANG Ying;HU Xiuhua;YANG Kairui;Beijing University of Chinese Medicine;;Effects of Astragalus Injection on Cell Proliferation and Migration in Human Melanoma A375 cells[J];辽宁中医杂志;2015-04
5 LI Zhi-gang;QIU Zuo-cheng;ZHANG Wei;XIA Kuan-hong;JI Yong;LI Ling;Department of Expert Outpatient Service, Uygur Autonomous Region Hospital of traditional Chinese Medicine;The Animal Experimental Center of Xinjiang Medical University;Medical experimental Teaching Center of Medical College of Shihezi University;;The effect of traditional Chinese herbs Huayu Liqi compound on the methylation and expression of p16 in gastric mucosal dysplasia rats cells[J];中国现代医学杂志;2015-07
6 CHEN Shulei;GAO Ping;WANG Tao;The First Clinical Medicine College of Henan University of TCM;Hematology and Oncology Department,the First Affiliated Hospital of Henan University of TCM;;Research Progress on Antitumor Active Ingredients of Astragalus and Their Mechanism[J];中国中医药现代远程教育;2015-05
7 Ya-Yun Guo;Mu-Xin Wei;Department of Chinese Medicine, the First Affiliated Hospital of Nanjing Medical University; Institute of Combined Traditional Chinese and Western Medicine of Nanjing Medical University;;Effect of Huatan Xiaoyu Fang on expression of Notch1, β-catenin and PTEN in precancerous lesions of gastric cancer in rats[J];世界华人消化杂志;2015-02
8 HU Ping;LENG Xiumei;HAO Chuanzheng;WEI Muxin;The Affiliated Hospital of Nantong University;The First Affiliated Hospital of Nanjing Medical University;;Efficacy Observation of Therapy of Activating Blood and Eliminating Stagnanation in Treating All Syndromes of Precancerous Lesions of Gastric Cancer[J];辽宁中医药大学学报;2014-09
9 LI Zhi-gang;ZHANG Wei;QIU Zuo-cheng;JI Yong;LI Ling;XIA Kuan-hong;Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine;;Effect of “Jiedu Huayu Jianpi Decoction”on demethylation and inducible expression of Thbs1 and E-cad gene in gastric mucosa dysplasia rats cells[J];上海中医药杂志;2014-07
10 Liu Hao;Wang Xia;Fan Yaofu;Wei Muxin;Nanjing Medical University;The First Affiliated Hospital of Nanjing Medical University;;Effect of eliminating Phlegm and blood stasis prescription on Expressions of Caspase-3,Cyclind1 and mTOR in Rats with Precancerous Lesions of Gastric Cancer[J];中医学报;2014-07
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 WANG Zhi-kun1,LIU Qi-quan1,LI Bo-lin2,DONG Lin-lin2,WU Yun-chu2,ZHANG Xiao-li1,SU Jun3(1.TCM Hospital of Heibei Province,Shijiazhuang 050011,China;2.Hebei Medical University,Shijiazhuang 050011,China;3.Renmin Hospital of Guangping,Guangping 057650,China);Effect of Eliminate Turbid Fluid and Remove Toxicity of Xiaoguishao on EGFR and VEGF in Rats with Gastric Carcinoma Precancerosis[J];中国中医药信息杂志;2012-12
2 YE Guoliang1,SHENG Hong2,ZHANG Xinjun1,ZHENG Tuo1,JIN Yanping1 1.Department of Gastroenterology,the Affiliated Hospital of Medical College Ningbo University,Ningbo 315020;2.Digestive Endoscopic Center,the First People's Hospital of Xiangshan,China;The clinical application and evaluation of endoscopic submucosal dissection in treatment of gastric intraepithelial neoplasia[J];胃肠病学和肝病学杂志;2012-04
3 LV Bin.Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Traditional Medical University,Hangzhou(310006);Gastric Intraepithelial Neoplasia:Evolvement and Reversal Treatment[J];胃肠病学;2011-10
4 Lü Lin-mao1,CAO Zhi-qun1,WANG Shu-min1,XIANG Hong-jie1,FANG Xin2(1Department of Endoscopy,the Affiliated Hospital of Shandong University of TCM,Jinan250011,China;2Neurosurgery Department,the Second Affiliated Hospital ofShandong University of TCM,Jinan 250001,China);Clinical study of Qilianshupi Decoction on treating precancerous lesion of gastric cancer[J];中国中西医结合消化杂志;2011-01
5 Tang Haifeng~1,Ma Ning~1,Tian Ye~1,Yuan Weihua~1,Yi Yanghua~2,Zhang Shuyu~2, Pan Minxiang~2,Han Hua~2,Cheng Guang~3,Lin Hong~3,Zhou Jie~3, Qiu Feng~4,Yao Xinsheng~4,Lin Houwen~5,Wang Xiaojuan~6 (1.Department of Pharmacy,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China; 2.Research Center for Marine Drugs,College of Pharmacy,Second Military Medical University, Shanghai 200433,China; 3.Department of Neurosurgery,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China; 4.Department of Phytochemistry,Shenyang Pharmaceutical University,Shenyang 110015,China; 5.Department of Pharmacy,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China; 6.Department of Pharmacy,School of Stomatology,Fourth Military Medical University,Xi'an 710032,China);Anti-glioblastoma-the Breakthrough Point in Pursuing New Anticancer Drugs from Saponins?[J];世界科学技术(中医药现代化);2010-06
6 LI Su-yan 1,JIANG Jian-kun2,LIN Yao-guang1,ZHANG Jun-hong1,LI Ping 2,JIANG Dunke1(1 Department of Geratologous Gastroenterology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;2 Department of Pathology,First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China);Expression of Epidermal Growth Factor Receptor in Pathological Change before Gastric Carcinoma and its Clinical Significance[J];广西医学;2010-07
7 Yan-Min Wu,Mu-Xin Wei,Department of Traditional Chinese Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China;Advances in research on gastrointestinal cell biology by integrated Chinese and Western medicine[J];世界华人消化杂志;2010-14
8 DU Zhong-hong,WEI Xiao-pin,HUI Qi-yuan Department of Pathology,Medical College of Yanan University,Yan' an 716000,China.;Advance in pathological mechanism and mass screening of gastric precancerous lesions[J];现代肿瘤医学;2010-04
9 CHU Yan-liu,ZHANG Juan,LIU Xiang-yang,GAO Xiao-zhong,LIU Feng,LIU Jie.Department of Gastroenterology,Weihai Municipal Hospital,Weihai 264200,China;Narrow band imaging endoscopy in diagnosis of atrophic gastritis and intestinal metaplasia[J];中国实用内科杂志;2010-03
10 Da-wei JU1,Pin-kang WEI1,Hui-ming LIN1,Da-zhi SUN1,Shan YU2,Li-juan XIU1 1.Department of Traditional Chinese Medicine,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China2.The 309th Hospital of People's Liberation Army,Beijing 100091,China;Effects of Xiaotan Sanjie Decoction on expressions of interleukin-8 and its receptors in gastric tumor xenografts and gastric tissue adjacent to the tumor in mice[J];中西医结合学报;2010-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved