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《Traditional Chinese Drug Research and Clinical Pharmacology》 2019-12
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The Active Mechanism of Astragali Radix-Curcumae Rhizoma Herb Pair on Gastric Precancerous Lesions Based on Network Pharmacology

LI Jiali;YANG Zehong;YANG Liangjun;LI Siyi;LIU Wei;LIU Yang;PAN Huafeng;Science and Technology Innovation Center,Guangzhou University of Chinese Medicine;  
Objective To investigate the active ingredients and mechanisms of Astragali radix-Curcumae rhizoma herb pair in treating gastric precancerous lesions(GPL)based on the network pharmacology. Methods The main active ingredients of Astragali radix-Curcumae rhizoma herb pair were obtained by the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)website with the criteria based on oral bioavailability(OB)≥30%, drug-like(DL)≥0.18, combined with related literatures. The corresponding targets of the active ingredients were screened by the TCMSP and Swiss Target Prediction,and the UniProt database was used to query the human gene corresponding to each target protein. The targets of GPL were collected by Genecards database,mapped to the target genes of the active ingredients of Astragali radix-Curcumae rhizoma herb pair,and the active components-target network were constructed. Interactive protein-protein interaction network(PPI)was constructed by STRING website. The common target genes were subjected to gene ontology(GO)enrichment and Kyoto encyclopedia of genes and genomes(KEGG)pathway enrichment analyses by Enricher database. The target-pathway network was constructed using Cytoscape 3.6.1 software. Results 166 compounds,28 active components and 112 common target genes of Astragali radix-Curcumae rhizoma herb pair were obtained,as well as 26 key genes with a value of ≥30 in the PPI network were selected. There were 45 GO terms related to biological process in GO enrichment analysis.Enrichment analysis revealed that, there were 18 KEGG pathways, including pathways in cancer, PI3 K-Akt signaling pathway, p53 signaling pathway, etc. Conclusion Astragali radix-Curcumae rhizoma herb pair may involve in various physiological processes such as tumor cell proliferation and apoptosis to exert an intervention effect on GPL by multiple components,multiple targets and multiple pathways.
【Fund】: 广东省普通高校特色创新类项目(2018KTSCX040);; 广东省自然科学基金项目(2017A030313845);; 广州市科技计划项目(201803010055);; 国家自然科学基金项目(81673946)
【CateGory Index】: R285.5
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