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The Effect of Breviscapln on the Relaxation of Aortic Rings in Rats

Chen Yiyue; Wang Shentao; Zhen Wenshan;Zhu Yinhong; Fu Yongmei ;Jiang Tao(Department of Pharmacology, Medical and)Pharmaceutical College, Guangzhou 510224)  
The antagonism of five kinds of vasodilators against the vasoconstriction induced byphenylephrine and barium chloride was studied. The results showed that the action ofbreviscapin (Bre) was similar to that of trifluoperazine (TFP), chiefly inhibiting therelease of intracellular calcium. In the experiment of eliminating vascular endothelium,it was found that the vasodilating action of Bre was independent of the integrity ofvascular endothelium, which was similar to that of TFP, cinnarizine and nifedipine, andthe dose-response curve of Bre was paralled to that to TFP. However, Bre did notantagonize the vasoconstriction induced by 5-HT, and TFP also elicited no antagonismin low dosage but markedly shifted the dose-response curve to the right in high dosage.It is indicated that the mechanism of Bre is probably related to the antagonism againstcalmodulin .
【CateGory Index】: R285.5
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