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《TRADITIONAL CHINESE DRUG RESEARCH & CLINICAL PHARMACOLOGY》 1998-03
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Effects of Polysaccharides in Astragulus on the Formationof Colony-Forming Units of Megakaryocytes (CFU-MK)in Mouse

Hong Jiemin, Wang Peixun, Qiu Jianxing, et al.(Guangdong Institute of TCM, Guangzhou 510095)  
Observing the effect of polysaccharides in Astragalus on the formation of colony-forming units of megakaryocytes (CFU-MK)in mouse bone marrow in vitro with methyl cellulose semisolid culture, the results showed that at the concentration of 25 mg/L in vitro, polysaccharides in Astragalus stimulated the formation of CFU-MK. Compared with the control, the amount of CFU-MK in mice increased obviously when the injected dose was 20 mg/kg or 100mg /kg for 3 days, but polysaccharides in Astragalus showed no protective effect on CFU-MK decreased by cyclophosphamide .It was suggested that polysaccharides in Astragalus can promote the formation of CFU_MK in mouse but can not relieve the inhibition of cyclophosphamide on CFU_MK.
【Fund】: 广东省中医药管理局科研项目
【CateGory Index】: R392.12,
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