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《Acta Academiae Medicinae Zunyi》 2004-04
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Study on the protective effects of pre-supplement zinc on liver lipid peroxidation damage of rat induced by cadmium

LI Hong, WANG Ke-yue, SHI Xiu-quan(Department of Preventive Medicine, Zunyi Medical College, Guizhou Zunyi 563003, China)  
Objective To make the acquaintance of lipid peroxidation damage of cadmium and the antagonistic action of pre-supplement zinc on the damage induced by cadmium in rat liver. Methods Thirty-six Wistar rats were randomly divided into six groups: control group, pre-supplement zinc group, low dose cadmium group (0.5mgCd/kg), low dose cadmium with pre-supplement zinc group, high dose cadmium group (2mgCd/kg) and high dose cadmium with pre-supplement zinc group. Liver was used to detect the content of malony diadehyde(MDA) and the activity of superoxide dismutase (SOD) in the groups of cadmium injection and cadmium injection with pre-supplement zinc. Results The content of MDA increased after cadmium injection and the levels of cadmium is positively correlated with MDA in liver(r=0.49,P0.05). The activity of hepatic SOD decreased after cadmium injection and the levels of cadmium is negatively correlated with SOD in liver(r=-0.489,P0.05). The content of MDA decreased and the activity of SOD increased in some degree in the groups of cadmium injection with pre-supplement zinc. Conclusions There was protective effect of pre-supplement zinc on liver lipid peroxidation damage of rat induced by cadmium.
【Fund】: 遵义医学院科研基金资助项目 (NO :F - 0 6 0 )
【CateGory Index】: R96
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