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《Acta Academiae Medicinae Zunyi》 2012-05
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Gynostemma improves vascular dementia-induced cognitive dysfunction in mice

Qi minfang,Luo chanlan,Qin wei,Tian hong,Chen yuanshou (Department of Physiology,Zunyi Medical College,Guizhou Zunyi 563099,China)  
Objective To investigate the neuroprotective effects of gynostemma on vascular dementia-induced cognitive dysfunction and neuronal injury in mouse hippocampal CA1 region.Methods C57BL/6 mice were randomly divided into sham-operation group(control),the vascular dementia(VD) group and gynostemma-treated(low,medium and high dose) groups.The mouse vascular dementia model was induced by bilateral common carotid artery occlusion(2VO).Morris water maze was used to measure mouse learning and memory ability.The neuronal injure in mouse hippocampal CA1 region was detected by HE staining.Results The Morris water maze test showed that vascular dementia induced the decreased spatial learning and memory ability and the delayed neuronal death in hippocampal CA1 region.Gynostemma treatment significantly improved cognitive dysfunction and reduced neuronal death in hippocampal CA1 region of VD mice.In addition,compared with the low dose of gynostemma group,the reduced escape latency and the increased times of crossing the platform were detected in high and medium doses of gynostemma groups.Conclusion Gynostemma could produce neuroprotective effects against VD-induced mouse cognitive dysfunction and neuronal injury.
【Fund】: 贵州省科学技术基金资助项目(NO:J20122351);; 遵义医学院重点学科建设经费资助项目(NO:20121602)
【CateGory Index】: R285
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