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《Journal of Zunyi Medical University》 2014-06
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Effects of continuous administration of cadmium from the parental generation to first filial generation on lipid peroxidation damage in rats

Zhang Yan;Wang Keyue;Department of Toxicology,School of Public Health,Zunyi Medical University;  
Objective To study the effects of continuous administration of cadmium( Cd) from the parental generation to first filial generation on lipid peroxidation damage in rats. Methods Thirty- six eight- week- old SD rats were randomly divided into four groups: no cadmium in feed group( group 1),cadmium( 1 mg / kg) in feed group( group 2),cadmium( 5 mg / kg) in feed group( group 3) and cadmium( 25 mg / kg) in feed group( group 4). Male and female rats were fed separately. One month later,two male and one female rats in the same group were placed in one cage to obtain pregnant rats. After ablactation,the offsprings were given the same feed as their parents until 8 weeks. The contents of malondialdehyde( MDA) and Zinc( Zn) in the brain and Cd in the kidney,liver and brain of the parents and offsprings were measured. Results Compared with group 1,the content of Cd was increased and Zn level was decreased in the brain and the content of MDA in the brain was increased in 2,3 and 4 groups. MDA content in the brain was significantly positively correlated to brain Cd( r =0. 69,P 0. 05),renal Cd( r = 0. 78,P 0. 05) and liver Cd( r = 0. 58,P 0. 05) and significantly negatively correlated to brain Zn( r =- 0. 11,P 0. 05). Conclusion Continuous administration of Cd from the parental generation to first filial generation could result in rat brain lipid peroxidation damage.
【Fund】: 贵州省科学技术基金项目(NO:黔科合J字[2013]2317)
【CateGory Index】: R114
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