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《Pharmacology and Clinics of Chinese Materia Medica》 1990-06
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NOOTROPIC EFFECT OF DANGSHENG, CODONOPSIS PILOSULA (FRANCH.) NANNF

Zhang Lei Liu Ganzhong (Department of Materia Medica & Pharmacology,Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029)  
Twenty Percent alcohol extract of Dangshen (DS-A) was used for facilitation of memory tested by one trail passive avoidance response (step down test) in mice and operant conditional reflex (fixed ratio) in rats. The extract reduced the impairment of acquisition of memory produced by scopolamine (SCPL), the disruption of consolidation of memory caused by sodium nitrite and the deficit of retrieval of memory induced by alcohol. And also, DS-A could improve operant conditional reflex impaired by SCPL. Similar effects were observed with the n-butyl alcohol extrect (DS-FIII), further purified from DS-A, of the drug. It suggested that the active components of Dangshen may be in DS-FIII. Effect of DS-FIII on M-cholinergic receptors were measured by radioligand receptor assay (RRA).No specific binding; of DS-FIII to M-receptor was observed. However, 5 days after ip injection of DS-FIII higher Bmax values were observed. Effects of DS-FIII and SCPL on Ach content of cortex and hippocampus were measured by radioimmunoassay(RIA) .SCPL reduced the Ach content in cortex and hippocampus markedly. Whereas, DS-FIII could not affect the reduction and raise the Ach content. The results suggested that one of mechanisms of action of Dangshen on memory facilitation may be related to cholinergic system. But, the mechanism of the nootropic action of Dangshen is very complicate and need to be further studied.
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【References】
Chinese Journal Full-text Database 5 Hits
1 CUI Ying (Henan College of Traditional Chinese Mdeicine,Zhengzhou,Henan,China,450008);The Intelligence-improving and Anti-aging Function of Drugs for Nourishing Yin and the Study Concerned[J];Henan Traditional Chinese Medicine;2002-03
2 Zhang Lihui (Dapartment of pharmacology Hangzhou ,Medical college Zhang Shishan) (Department of pharmacology,Wenzhou Medical college );Comparative Study of Facilitatory Effect between Codonopsis Pilosula and Ginseng[J];JOURNAL OF HANGZHOU MEDICAL COLLEGE;1998-01
3 LIU Mengyuan 1, WANG Daping 2, LIU Yuping 2, FENG Peiling 2, YANG Dongying 2 (1.Guangzhou Institute of TCM, Guangzhou 510130, China;2.Guangzhou Hospital for Mental Diseases, Guangzhou 510130, China);Effects of Modified Danggui Shaoyao Powder for Alzheimer's Disease[J];Journal of Guangzhou University of Traditional Chinese Medicine;2001-01
4 Zhou Fang,Jia Hongxiao,Tang Yunyi,Zhang Jizhi,Jiang Zhenkang(Beijing Anding Hospital,Capital Medical University);Clinical Observation on Improving the Memory Impairment of Patients with Schizophrenia by Si Junzi Tang[J];Journal of Capital Medical University;2008-04
5 Jia Hongxiao1,He Shuchang2,Tang Yongyi1,Jiang Zhenkang1,Zhang Jizhi1(1.Beijing Anding Hospital,Capital Medical University;2.Department of Psychological,Peking University);Effect of Jianpibushenfang on Ketamine-induced Memory Impairment in Mice[J];Journal of Capital Medical University;2009-01
【Citations】
Chinese Journal Full-text Database 1 Hits
1 YANG Xiao-min, LUO Zhi-pu, ZHOU Jin-huangInst of Pharmacology and Toxicology, Academy of Military Medical Science, Beijing, 100850;Potentiating effect of clonidine on anxioytic action of diazepam in the rat anxiety model of conditioned fear response[J];Chinese Journal of Pharmacology and Toxicology;1988-03
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 YANG Xiao-min,LUO Zhi-pu,ZHOU Jin-huang(Inst of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850);Involvement of central norepinephrine system in the anxiolytic action of benzodiazepines[J];Chinese Journal of Pharmacology and Toxicology;1988-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Wang Shaogen,Chen Xiaying,Wang Liji,Wang Changrong,Wang Yongjie (The First Affiliated Hospital,Anhui Medical University,Hefei 230022);EFFECT OF CODONOPSIS PILOSULA ON GASTROINTESTINAL MOTILITY IN Ⅲ  BURN RATS[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;1999-06
2 NIE Song liu,XU Xian xiang,XIA Lun zhu (Hospital of Lu′an City,Anhui Lu′an 237000,China);EFFECT OF TOTAL SAPONINS OF CODONOPSIS ON BLOOD LIPID AND NITRIC OXIDE LEVEL IN EXPERIMENTAL HYPERLIPEMIA RATS[J];Journal of Anhui Traditional Chinese Medical College;2002-04
3 Xu Jianlin, Zhou Yingbin, Xu Luo, et al Department of Physiology, Qingdao Medical College, Qingdao 266021;EFFECTS OF SEMEN ZIZYHYI SPINOSAE LIQUOR ON LEARNING AND MEMORY IN ISOLATED RATS[J];;1997-02
4 Liu Renyi Hsu Pinghsuan (Shanghai Brain Research Institute, Academia Sinica);EFFECTS ON LEARNING AND MEMORY OF ELECTROLYTIC LESIONS OF HIPPOCAMPUS IN RATS[J];Zoological Research;1982-04
5 CHEN Yu xiang 1,ZHANG Li ping 2, LIANG Zhong yan 2, MIAO Chun yan 2, ZHANG Yi shen 2 (1 Jilin University of Technology Bilolgy Resource Enginecring, Changchun 130025, China; 2 College of Life Science, Northeast Normal University, Changchun;Structure investigation of water soluble polysaccharide H_n isolated from the fruits of Hippophae rhamnosides L[J];JOURNAL FO MOLECULAR SCIENCE;2000-01
6 Xu Zhen-Rong Depertment of pharmacology Guangdong Medical and Pharmaceutical College;THE EFFECT OF CODONOPSIS PILOSULA ON THE BLOOD LIPIDS[J];;1985-02
7 Feng Binghong, Li Weixuan, Luo Jian 1 (Guangdong College of Pharmacy, Guangzhou,P R China 510224) [BHDWG16,WK46ZQW];Comparison of Effects of Scopolamine and GynosaponinXLⅢ on Levels of Glu/GABA in Memory Regulation System of Mice[J];ACADEMIC JOURNAL OF GUANGDONG COLLEGE OF PHARMACY;1998-02
8 Gansu College of TCM Lanzhou (730000) Bai Juan Qiu Tong Li Ping Jiang Yeng;A Laboratry Study of Codonopsis on changes of Qi and Blood and Acid-base in RDS of rats[J];Journal of Gansu College of Traditional Chinese Medicine;1993-03
9 (Dedpartment of Patholagy) Bai Juan;Qiu Tong ;li Ping;Effects os Codonopsis on Changes of Alveolar-arterial Oxygen Gradient aud Blood-air Barrier in Rats with Respiratory Distress Syndrome[J];JOURNAL OF GANSU COLLEGE OF TRADITIONAL CHINESE MEDICINE;1994-01
10 Wang Lin-song et al(Department of Biology,Henan Normal University,Xinxong 453000);THE EFFECTS OF RADIX REHMANNIAE AND EUCOMMIA ULMOIDES OLIV ON CELL IMMUNE FUNCTION OF RHESUS MONKEY[J];HENAN MEDICAL RESEARCH;1994-01
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Yang Xianling Red Cross Taiwangnese Hospital,Xiangshan County,Zhejiang Province(315731);Review on Chinese Medicine Treating Senile Dementia[J];Journal of Zhejiang University of Traditional Chinese Medicine;2007-01
2 HU Hanbo, WANG Miqu, LIAO Fangzheng Basic Medicine College, Chengdu University of TCM (Chengdu, 610075,China);From the View of the Affection on Praxiological Changes of Filial Generation Mice by Terroring Pregnant Mother Mice to Consider the Etiopathogenesis of Senile Dementia[J];JOURNAL OF CHENGDU UNVERSITY OF TARDITIONAL CHINESE MEDICINE;1999-01
3 ZHANG Xi-mei, Li Lin, CHEN Ling, MIAO Xiao-jie (College of Light Industry and Food Science, South China University of Technology, Guangzhou 510640);Study on the Extaction of Total Flavones from Pueraria Lobata Ohwi[J];Modern Food Science and Technology;2008-01
4 SU Jie.Jiangsu Hospital of Combination of Traditional Chinese Medicine with Western Medicine,Nanjing 210028;Therapeutic effect of combination of traditional Chinese medicine with western medicine on infantile autumn diarrhea.[J];Hebei Journal of Traditional Chinese Medicine;2002-10
5 SONG Guoying 1) ,WANG Chunyao 2) ,FANG Guiyuan 3) ,LIU Hua 1) 1)Department of Biology,Henan Medical University,Zhengzhou 450052 2)Laboratory Animal Center,Henan Medical University,Zhengzhou 450052 3)Department of Neurology,the First;Pharmacological effect of Tongmaizengzhi capsule[J];Journa of Henan Medical University;2000-06
6 Fang Guiyuan1),Li Jicheng2),Lin Zetian3),Liu Hua4),Song Gouying4),Wang Zuosheng1),Lu Hong1)1)Department of Neurology,the First Affiliated Hospital,Henan Medical University,Zhengzhou 4500522);Clinical study of Tongmaizenzhi capsule in treating patinents with vascular dementia[J];JOURNA OF HENAN MEDICAL UNIVERSITY;1997-04
7 ;Research Progress in the Treatment of Senile Dementia With Common Chinese Herbs[J];Hunan Guiding Journal of Traditional Chinese Medicine and Pharmacology;2004-10
8 Fang Guiyuan (the First Affiliated Hospital of Henen Medical University (450052 ))Lin Zetian Zhenzhou (Public Health Bureau(450052))Li Jicheng;Liu Hua;Song Guoying (Henan Medical University(450052));A Clinical Study of Tongmai Zengzhi Capsules Applied in the Treatment of Dysmnesia Caused by Vascular Dementia[J];HENAN TRADITIONAL CHINESE MEDICINE;1997-06
9 WANG Xiao-Lei~①,BAI Lin,CHEN Li-Ping,YI Jun(~①Department of Pharmacy Chinese Medicine,PLA General Hospital,~②Department of Traditional Chinese Medicine,~③Department of Cardiology Chinese Medicine, Beijing 100853 China);Protective Effect of Yixinyin on Myocardial Ischemia-Reperfusion Injuries[J];Pharmaceutical Journal of Chinese People's Liberation Army;2005-03
10 CHEN Li-Ping~,GAO Li-Ping,YI Jun~②,LIU Ping (~Department of Traditional Chinese Medicine,PLA General Hospital,~②Department of Cardiology PLA General Hospital,Beijing 100853 China);Effect of Yixin Oral Herbs on Experiment Arrhythmia of Mice[J];Pharmaceutical Journal of Chinese People's Liberation Army;2006-04
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