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The Antiaging Effects of Pearl-powder on mice aging model Induced by D-Glactose or Ozone

Li Duan, Xu Xiang, Li Dan, Sun Jianguo, Wu Peijun, Lu Jing(Department of pharmacology, School of pharmacy, Shanghai Medical University, Shanghai 200032)  
The subacute D-galactose-aging or Ozone-aging mice models were formed respectively after mice were injected (sc) with D-galactose 40mg/kg, qd×40d or exposed in the environment of ozone (O_3) with the density of 0.53±0.12mg/m~3, 8h/d×15d. At the same time, Pearl-poeder 50,100,200mg/kg (ig) were given in D-galactose-aging mice model qd×40d or in Ozone-aging mice model qd×15d respectively. And then, the activity of Glutathine Peroxidase (GSH-Px) in whole blood, the contents of Malondialdehyde (MDA) in serum and Lipofuscin of heart, liver and brain tissues in mice were measured. Contrast to the D-galactose-aging mice model group, it showed that the activities of blood GSH-Px were significantly increased (P0.01) after administration of pearl-powder 100,200mg/kg. The contents of seurm MDA were significantly decreased after administration of pearl-powder 200mg/kg (P0.01). The contents of lipofuscin of heart tissue were siginificantly decreased after administration of pearl-powder 100,200mg/kg (P0.05 or P0.01). The contents of lipofuscin of brain tissue were significantly decreased in pearl-powder 50,100,200mg/kg groups (P0.01). Contrast to the ozone-aging mice model group, it showed that the activities of blood GSH-Px were significantly increased after administration of pearl-powder 50,100,200mg/kg (P0.05 or P0.01). The contents of serum MDA were significantly decreased after administration of pearl-powder 100,200mg/kg (P0.01). The contents of liver lipofuscin were significantly decreased after administration of pearl-powder 100mg/kg (P0.01). But there were no significant decreasing effects of lipofuscin in heart tissue and brain tissue.
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