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Effect of Ganoderma polysaccharides on inositol trisphosphate and diacylglycerol in murine peritoneal macrophages

Li Mingchun,Lei Linsheng 1,Wang Qingbiao 1,Liang Dongsheng,Xu Ziming,Yang Shuqin 1,Sun Lisha 1 (Department of Pharmacy, 401 Hospital of PLA,Qingdao 266071; 1 Department of Pharmacology,First Military Medical University, Guangzhou 510515))  
Objective: Through investigation the effect of GLB 7 on inositol trisphosphate (IP 3) and diacylglycerol (DAG) in murine peritoneal macrophages to provide a scientific evidence for it's immnomodulatory mechanism.Method: Cell culture, radioimmunological asssy, anion-exchange columns and thin-layer chromatography were used.Result: GLB 7 increased the production of IP 3 and DAG in murine peritoneal macrophages.The peak time of IP 3 was 30s, pertussis toxin (PTX) could inhibit GLB 7 from increasing the production of IP 3. In the production of DAG, two peak had been seen, the first peak was rapid and transitory, and the second was sluggish.Conclusion: The both path of signal transduction of IP 3/Ca 2+ and DAG/PKC are participated in the immunomodulatory of GLB 7 to macrophages.
【Fund】: 国家自然科学基金
【CateGory Index】: R285
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