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《Pharmacology and Clinics of Chinese Materia Medica》 2008-02
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The Effect of Rehmannia glutinosa oligosaccharides on learning and memory abilities and cerebral ACh in rat with vascular dementia

Shi Haiyan,Li Ying,Shi Jialin,Yang Jing(The Key Laboratory of Molecular Biology and New drug R&D,Liaoning Medical College,Jinzhou 121004)  
Objective: to observe the effect of Rehmannia glutinosa oligosaccharides(ROS) on learning and memory abilities and ACh in rat hippocampus with vascular dementia(VD).Methods: Rat model of VD was established by repeated ischemia/reperfusion and pretreated with sodium nitroprusside;the learning and memory abilities were tested by water maze;the content of Ach was determined by alkaline hydroxylamine.Results: Compared with the sham operation group,the model group's learning and memory ability was significantly decreased,Compared with the model group,the rats of the sham-operation group and ROS group showed the content of Ach in hippocampus were significantly increased.ROS significantly improved the learning and memory abilities in rat with VD,and the contents of ACh were increased.Conclusion: ROS can improve the spatial memory of rat which may be related to its effect of increasing ACh in hippocampus.
【Fund】: 辽宁省高校分子细胞生物学与新药开发重点实验室开放课题(2006LY07);; 辽宁医学院博士启动课题
【CateGory Index】: R285
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【References】
Chinese Journal Full-text Database 1 Hits
1 LIU Wei-xin,LU Yan-wei,DU Hai-tao,WU Zu-ze(Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing 100850,China);Pharmacological actions of Radix Rehmanniae and its active components:research advances[J];Journal of International Pharmaceutical Research;2009-04
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Wang Rui(王 蕊), Yang Qinfei(杨秦飞), Tang Yipeng(唐一鹏), et al.(Beijing University of Traditional Chinese Medicine, Beijing 100029);Establishing of the Imitative Vascular Dementia Rat Model and the Preliminary Study on the Preventive and Treating Effects of TCM Preparation 9602 on the Disease[J];JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;2000-05
2 CHENG Xiao-rui, ZHOU Wen-xia, ZHANG Yong-xiang (Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China);The effects of Liuwei Dihuang decoction on the differential expression genes in the hippocampus of senescence-accelerated mouse[J];Chinese Pharmacological Bulletin;2006-08
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 HE Feng Tutor:YANG Jun, XU Guan sun, SHEN De kai (Second Clinic Department, Anhui College of Traditional Chinese Medicine, Anhui Hefei 230038, China);INFLUENCE OF ELECTROACUPUNCTURE ON LEARNING AND MEMORY FUNCTION AND CEREBRAL BLOOD FLOW IN VASCULAR DEMENTIA RATS[J];Journal of Anhui Traditional Chinese Medical College;2002-03
2 HUANG Qiong (Medcical College, Hubei Institute for Nationalities, Enshi, Hubei, 445000, China);Mechanism of Fufang Danshen to Vascular Dementia Rats'Cranial Nerve Cell Apoptosis[J];Journal of Hubei Institute For Nationalities Medical Edition;2002-04
3 Fang Kaiyun, An yuwen,Wang Yang, et al. The Affiliated Hospital of Guiyang Medical College, Guiyang 550004;The study on effect and mechanism of enflurne to rabbits hemodynamics on the pulling gallbladder[J];Guizhon Medical Journal;2003-01
4 XIE Xiang-lin1,ZHOU Ming2,HONG Tie1,MA Chun-ying1,YE Qiu-fang1,ZHAO Li1,LIU Hong-yan1(1.Department of Pharmacology,School of Pharmacy,Jilin University,Changchun 130021,China;2.Development Center of New Drugs,First Affiliated Hospital,Changchun University of Chinese Medicine,Changchun 130021,China);Effect of captopril orally administered for long term on learning and memory function of normal adult mice[J];Journal of Jilin University(Medicine Edition);2010-03
5 GONG Zhenling,LI Xingqin,JIN Guochun, et al. Hospital Affiliated to Institute of TCM of Zhengding County,Hebei, Zhengding,050800;Study of the preventive and therapeutic effects of traditional Chinese medicine-Chidaikang on vascular dementia in rats[J];Hebei Journal of Traditional Chinese Medicine;2004-03
6 GONG Zhen-ling, et al (The Affiliated Hospital to The TCM Institue of Zhengding,Hebei Zhengding 050800,China);Effect of Chidaikang on the levels of ET-1 and CGRP of brain tissue in vascular dementia rats[J];Hebei Medicine;2004-02
7 WANG Yan, CAO Zhao-jin, WANG Qiang, et al. Office for Public Health Management, Chinese Center for Disease Control and Prevention, Beijing 100050, China;Effects of 915 MHz Electromagnetic Fields on the Concentration of Neurotransmitters in the Brain Tissue of the Mice[J];Journal of Environment and Health;2007-10
8 Feng Yinman,Long Xuyang,Zheng PanHenan TCM College;Recent Progress in TCM Experimental Research of VD (vascular dementia)[J];Journal of Henan College of Traditional Chinese Medicine;2004-01
9 Zhou Xiaoqing, Liu Wanghua, Li Hua, et al (Hunan College of Traditional Chinese Medicine, Changsha Hunan 410007);An Experimental Study on the Effects of DLXNP on Learning and Memory Ability and Cerebral EAAs in Rat Models of Vascular Dementia[J];Journal of Hunan College of Traditional Chinese Medicine;2002-02
10 Liu Wanghua, Zhou Xiaoqing, Li Hua, et al (Institute of Diagnosis of TCM, Hunan College of TCM, Changsha, Hunan 410007)[BHDWG4mm,WK40W] 〔;An Experimental Study on the Effects of DLXNP on the Blood Rheologic Characteristics in Rat Models with Vascular Dementia[J];Journal of Hunan College of Traditional Chinese Medicine;2002-04
China Proceedings of conference Full-text Database 1 Hits
1 FANG Heng-tong JIANG Yu-gang PANG Wei LIU Jing Institute of Hygiene and Environmental Medicine,Academy of Military Medical Sciences,Tianjin 300050,China;STUDY ON THE EFFECT OF COMBINED NUTRIENTS ON COGNITION AND MOTOR FUNCTION AND ITS MECHANISM IN AGED RATS[A];[C];2007
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 LI Wei, WANG Xiu-li, WANG Qing, LI Ji-jun, LI Zhong-xing, SHAN Bao-en(General Hospital of Coal Industry Ministry of China, Beijing 100028, China);Influence of Radix Rehmanniae Preparata Water Extract on TNF-α Produced by Monocytes of Balb/C Mice[J];Labeled Immunoassays and Clinical Medicine;2009-01
2 Miao Mingsan Sun Yanhong Shi Jingjing Liu Huili(Henan College of Traditional Chinese Medicine,Zhengzhou 450008);Effects of Gross Polysaccharide of Radix Rehmanniae Preparata on Morphology Changes of Thymus and Spleen in Blood Deficiency Model Mice[J];China Journal of Traditional Chinese Medicine and Pharmacy;2007-05
3 WANG Tai xia 1,2 , LI Jing yuan 1, HU Zheng hai 1* (1 College of Life Science, North West University,Xi′an 710069,China; 2 College of Life Science,Henan Normal University, Xinxiang,453002,China);Morphogenesis and structural development of the root tuber of Rehmannia glutinosa cv. Hueichingensis[J];Acta Botanica Boreali-occidentalia Sinica;2003-07
4 Xiao Ling;Zhao Xiangui and Chang Siming(Northwestern College of Forestry, Yangling, Shaanxi 712100);DEVELOPMENTAL ANATOMY OF THE ROOT TUBER OFREHMANNIA GLUTINOSA[J];ACTA BOTANICA BOREALI-OCCIDENTALIA SINICA;1996-05
5 ZHANG Yan ling, LI Lu si, KE Jin xing, FAN Wen hui (Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Relationship of memory behaviors and changes of synapse structure in vascular dementia rats[J];Acta Academiae Medicinae Militaris Tertiae;2002-12
6 Guo Shunmin(Fujian Institute of Medical Science 350001) Guo Yaohui(Fujian Medicinal Materials Company 350003);Progress of Studies on Hypoglycemic Constituents of Natural Products[J];STRAIT PHARMACEUTICAL JOURNAL;2000-01
7 LIU Li-ping,HUANG Jian,CHEN Bi-lian,Huang Jian,Chen Bi-lian(College of Bioengineering,Fujian Normal University,Fuzhou 350007;China);Progress of Hypoglycemic Constituents of Natural Products[J];Strait Pharmaceutical Journal;2004-05
8 Yang Yanyan, Gao Shang, Wang Huiping, Chen Shan, Ma Lixin(School of Life Science, Hubei University, Wuhan 430062,China);Studies on the effect of konjac oligosaccharides on blood sugarand serum cholesterol in the diabetic mice[J];Journal of Hubei University(Natural Science Edition);2001-03
9 Cui Hao1,Feng Jing2,Cui Ying2,Wang Hui2,Shen Xiuli2,Sun Shuguang2,Jing Huijun2,Zhang Liwu2Huaibin Health School, Huaibin, Henan, China, 464400Henan College of Traditional Chinese Medicine, Zhengzhou, Henan, China, 450008;Inhibition Effect of Shu Dihuang and the Polysaccharide on CNS[J];Journal of Henan University of Chinese Medicine;2006-06
10 Cui Ying~1, Wang Junming~2, Feng Zhiyi~3, Ding Gang~4, Zhu Fengyun~1, Jing Huijun~1(1. Henan College of Traditional Chinese Medicine, Zhengzhou, Henan, 450008; 2. Postgraduate in Grade 2004, Henan College of Traditional Chinese Medicine, Zhengzhou, Henan, 450008;3. Postgraduate in Grade 2003, Henan College of Traditional Chinese Medicine, Zhengzhou, Henan, 450008;4. Center for Instrumental Analysis of China Pharmacy University, Nanjing, Jiangsu, 210009);Fever-reducing Function of Dihuang on Rabbit’s Fever of Extreme Heat Due to Yin Deficiency Syndrome[J];Henan Traditional Chinese Medicine;2007-01
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 WU Mi-shan1,ZHAO Su-zhi2,LI En3, BAI Xia1(1.Traditional Chinese Medicine College,3.Dept of Biochemistry,Hebei Medical University,Shijiazhuang 050091,China;2.Qiaodong District Hospital of Shijiazhuang,Shijiazhuang 050041,China);Effects of catalpol from Radix rehmanniae on proliferation,differentiation and matrix mineralization of MC3T3-E1 cells[J];Chinese Pharmacological Bulletin;2010-04
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