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《Pharmacology and Clinics of Chinese Materia Medica》 2008-02
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Serum pharmacochemistry studies on the anti-endotoxin components of Radix et Rizoma Rhei

Deng Chong,Wu Yi,Meng Xianli,Zhang Yi,Geng Zhipeng(Chengdu Universuty of Traditional Chinese Medicine,Chengdu 611137)  
Objective: To compared study on the chemical components of anti-endotoxin components of Radix et RizomaRhei in vitro and in vivo.Methods: By the using of HPLC fingerprinting,the compared research on the chemical components in vitro and in vivo of Decoction of Radix et Rizoma Rhei,extractum free anthraquinones and extractum bound anthraquinones has carried though,and also studied on the source of the chromartograghic peaks and the structures of the chemical compounds.Results: Chemical components in rats serum ig Decoction of Radix et Rizoma Rhei have been analyzed.The sources of 22 chromatography peaks have been found,and 5 compounds are metabolized produces.It is also discovered that the chemical components in rats serum ig solution suspended extractum free anthraquinones or extractum bound anthraquinones are same to each other.Aloe-emodin,rhein,emodin,and chrysophanol are the main existent format in the two serum samples.Conclusion: This experimental research is helpful to study on chemical componential foundation to efficacy.
【Fund】: 国家自然科学基金项目资助(3037175630772764)
【CateGory Index】: R285
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