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《Pharmacology and Clinics of Chinese Materia Medica》 2009-03
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Study on mechanism of Senecio scandens Buch-Ham against Escherichia coil with serum pharmacology

Zhang Wenping1, Liu Bolan2, Li Xiaohua1, Wang Xiaoli1, Huang Zeng1, Zhang Ruiqi1 (1 Department of Medical Microbiology,2 Department of Histology and Embryology, Gannan Medical College Gangzhuo 341000)  
Objective:To explore the antibacterial mechanism of Senecio scandens Buch-Ham(SSB) on Escherichia coil by serum pharmacological method. Method: Flavonoid compound was isolated from SSB, and then the serum contained water decoction agent of SSB or flavonoid compound were prepared with mice. By scanning electron microscope (SEM), the effects of drug-containing serum on the ultrastructure of E.coil were observed. By incorporation experiments of isotope-labeled precursor, the effects of drug containing serum on the biosynthesis of E.coil were observed as well. Meanwhile, the serum contained normal saline was set as negative control. Results: Compared with negative control serum, the morphology and ultrastructure of both drug containing serum on E.coil showed obvious changes such as cell surface rough, constriction or fracture. In addition, the synthesis of DNA, RNA, protein and peptidoglycan was inhibited. Conclusion: The antibacterial mechanism of SSB on E.coil may be involved with the inhibition of DNA, RNA, protein and peptidoglycan synthesis, its effective ingredients may be flavonoid compound.
【Fund】: 江西省教育厅科学技术项目NO:2006-253
【CateGory Index】: R285
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