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《Pharmacology and Clinics of Chinese Materia Medica》 2009-06
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Apoptosis induced by celastrol on multiple cell lines and the effect on cell cycle

Xie Yong(Medical College,Datong University,Datong 037009)  
Aim:To research the inhibition effect and the influence on cell cycle of the multiple myeloma cell lines,KMS12 and KMS18 by celastrol as well as the mechanism involved.Methods:The inhibition effect was measured with the CCK-8 kit,apoptosis was determined by staining with V-Annexin-FITCand PI labeling as well as the assay of sub-S1 phase.Cell cycle was determined by flow cytometer.Result :Cellular proliferation was inhibited by celastrol at low concentration undergoing apoptosis.Cell cycle was affected at S0 phase and S phase,as well as G2/M phase.Conclusion:Celastrol induced the apoptosis of MM cell lines in a relative low dose,thus has potential for clinic.
【Fund】: 山西省大同市科技局2006年基金项目
【CateGory Index】: R733.3
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