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《Pharmacology and Clinics of Chinese Materia Medica》 2010-05
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The research of Celastrol on its effect of inducing gastric cancer cell line MGC803 apoptosis

Xie Yong,Yan Yanyan,Yu Jiezhong,Ji Ning,Ma Cungen (Institute of Brain Science,Shanxi Datong University Department of diagnostics,Medical School,Datong 037009)  
Objective: Celastrol is a natural proteasome inhibitor.It is found that celastrol can decrease cell survival of leukemia,prostate cancer and multiple myeloma cell lines.Our study is designed to investigate whether celastrol can inhibit the survival of gastric cancer cell line MGC803.Methods: We investigated the action of celastrol against the survival of gastric cancer cell line MGC803 with MTT assay,Hoechst staining and western blot.Result: Celastrol decreases cell growth with IC50 of 4.69±0.38μM.Celastrol induces MGC803 cell line apoptosis demonstrated by hoechst staining,cleavage of PARP and the activation of caspase-3.Conclusion: Celastrol can decrease cell growth of gastric cancer by inducing it apoptosis.It is a potential natural product against gastric cancer.
【Fund】: 山西省回国留学人员科研经费资助项目(2010第14号);; 山西大同大学校级科学研究项目(2005第85号)
【CateGory Index】: R735.2
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