Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Pharmacology and Clinics of Chinese Materia Medica》 2010-05
Add to Favorite Get Latest Update

The research of Celastrol on its effect of inducing gastric cancer cell line MGC803 apoptosis

Xie Yong,Yan Yanyan,Yu Jiezhong,Ji Ning,Ma Cungen (Institute of Brain Science,Shanxi Datong University Department of diagnostics,Medical School,Datong 037009)  
Objective: Celastrol is a natural proteasome inhibitor.It is found that celastrol can decrease cell survival of leukemia,prostate cancer and multiple myeloma cell lines.Our study is designed to investigate whether celastrol can inhibit the survival of gastric cancer cell line MGC803.Methods: We investigated the action of celastrol against the survival of gastric cancer cell line MGC803 with MTT assay,Hoechst staining and western blot.Result: Celastrol decreases cell growth with IC50 of 4.69±0.38μM.Celastrol induces MGC803 cell line apoptosis demonstrated by hoechst staining,cleavage of PARP and the activation of caspase-3.Conclusion: Celastrol can decrease cell growth of gastric cancer by inducing it apoptosis.It is a potential natural product against gastric cancer.
【Fund】: 山西省回国留学人员科研经费资助项目(2010第14号);; 山西大同大学校级科学研究项目(2005第85号)
【CateGory Index】: R735.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 XIE Yong(Department of Diagnostic,Medicine School,DaTong University Datong,Shanxi,037009,China);The suppressive effect of Celastrol against Multiple Myeloma Cell Line RPMI8226 in vitro[J];Strait Pharmaceutical Journal;2011-06
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Xie Yong(Medical College,Datong University,Datong 037009);Apoptosis induced by celastrol on multiple cell lines and the effect on cell cycle[J];Pharmacology and Clinics of Chinese Materia Medica;2009-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Jingsong Wang and Michael A. Maldonado Translational Medicine, Wyeth Research, Collegeville, PA 19426, USA; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;;The Ubiquitin-Proteasome System and Its Role in Inflammatory and Autoimmune Diseases[J];中国免疫学杂志(英文版);2006-04
2 ZHANG Yao-quan,GUO Li-ping,YUAN Fa-huan (Department of Nephrology,Xinqaio Hospital,Third Military Medical University,Chongqing 400037,China);Relationship between expression of cathepsin B and urine protein in patients with chronic glomerular nephritis[J];Chongqing Medicine;2007-05
3 YI Wen-yuan, XU Bo, LI Min(State Key Laboratory of Natural and Biomimetic drugs, Peking University Health Science Center, Beijing 100083, China);Advancement of research into proteasome inhibitors in overcoming multidrug resistance of tumor[J];Foreign Medical Sciences(Section of Pharmacy);2007-02
4 XIE Yong(Department of Diagnostic,Medicine School,DaTong University Datong,Shanxi,037009,China);The suppressive effect of Celastrol against Multiple Myeloma Cell Line RPMI8226 in vitro[J];Strait Pharmaceutical Journal;2011-06
5 SUN Jin-Hua,CHENG Han-Hua,ZHOU Rong-Jia(Department of Genetics and Center for Developmental Biology,College of Life Sciences,Wuhan University,Wuhan 430072,China);Ubiquitin C-terminal Hydrolases L1:Physiological and Pathological Significance[J];Progress in Biochemistry and Biophysics;2007-08
6 Yingying Zhang Hengqi Zhu Lixia Zhao Xiaowei Zhou Peitang Huang Beijing Institute of Biotechnology,Beijing 100071,China;Generation of Mouse UBE2W Antibody and Analysis of UBE2W Expression in Mouse Tissues[J];Chinese Journal of Biotechnology;2008-04
7 Xiao-Qi Hong,Min Liang,Fang Huang(State Key Laboratory of Medical Neurobiology,Shanghai Medical College,Fudan University,Shanghai 200032,China);Function of Ubiquitin-protein Ligase in Nervous System[J];Chinese Journal of Cell Biology;2009-03
8 LU Ying, ZHAO Jian-ya, QIU Liang-lin, et al. (Public Health School, Nantong University, Nantong 226007, China);EFFECTS OF ZINC DEFICIENCY ON THE EXPRESSION OF UCH-L1 IN THE HIPPOCAMPUS OF RATS[J];Modern Preventive Medicine;2010-09
9 CAO Jian-nan,GUO Han-cheng.(Department of Nephrology,Teaching Hospital of Fujian Medical University,Xiamen Zhongshan Hospital,Xiamen 361004,China);Role of Ubiquitin-proteasome System in the NF-κB Signaling Pathway[J];Medical Recapitulate;2009-03
10 LIU Lei,FANG Yan-Qiu,XU Shu-Fen,et al.Central Laboratory,The First Hospital,Jilin University,Changchun 130021,Jilin,China;ODDD regulated herpes simplex virus-thymidine kinase/gancyclovir system killing effect on Hela cell line under hypoxia[J];Maternal and Child Health Care of China;2008-09
【Co-references】
Chinese Journal Full-text Database 1 Hits
1 Xie Yong(Medical College,Datong University,Datong 037009);Apoptosis induced by celastrol on multiple cell lines and the effect on cell cycle[J];Pharmacology and Clinics of Chinese Materia Medica;2009-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved