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《Pharmacology and Clinics of Chinese Materia Medica》 2012-06
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Study on the protective effect of rhoifolin against hepatic injury induced by triptolide

Gao Shuliang1,Lu Yuanyuan2,An Lijuan1,Shu Jicheng2,Liu Jianqun2,Zhang Rui2,Ren Xiaojing2(1 School of Basic Medical Sciences,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004;2 Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004)  
Objective: Study on the protective effect of rhoifolin against hepatic injury induced by triptolide.Method: The protective effects of rhoifolin at the concentration of 75,150,300μg/ml,on the in vitro damage of human L02 liver cells injured by triptolide at the concentration of 40μg/ml were evaluated with cell survival rates,which were determined by MTT assay.Sixty mice were randomly divided into six groups as follows: The drug groups mice were treated with rhoifolin for six day at the dose of 140,70,35mg/kg,respectively.The normal control group and the model control group took equivalent amount of distilled water by the same route.And mice in the positive control group were treated with 70mg/kg diammonium glycyrrhizinate.After the last administration,all groups except the normal control were administered with triptolide at dose of 0.625mg/kg by gavage to induce acute hepatic injury.Thereafter,the contents of ALT,AST in serum,the activities of SOD,MDA,GSH-Px and GST in the liver were measured and the hepatic histological changes were observed by optical microscope.Results: The cell survival rates of human L02 liver cells injured by triptolide and then treated with rhoifolin at the concentration of 75,150,300μg/ml were significantly increased.The contents of ALT,AST in serum were significantly decreased,the content of MDA in the liver was also significantly lowered,and the activities of SOD,MDA,GSH-Px and GST in liver were significantly improved after preventive treatment with rhoifolin at the dose of 140,70,35mg/kg.Rhoifolin can ameliorated the hepatic pathological changes.Conclusion: The protective effect of rhoifolin against hepatic injury induced by triptolide was significant in vitro and in vivo.
【Fund】: 国家自然科学基金资助项目(编号:30960495)
【CateGory Index】: R285
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