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《Pharmacology and Clinics of Chinese Materia Medica》 2012-06
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Study on the protective effect of rhoifolin against hepatic injury induced by triptolide

Gao Shuliang1,Lu Yuanyuan2,An Lijuan1,Shu Jicheng2,Liu Jianqun2,Zhang Rui2,Ren Xiaojing2(1 School of Basic Medical Sciences,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004;2 Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004)  
Objective: Study on the protective effect of rhoifolin against hepatic injury induced by triptolide.Method: The protective effects of rhoifolin at the concentration of 75,150,300μg/ml,on the in vitro damage of human L02 liver cells injured by triptolide at the concentration of 40μg/ml were evaluated with cell survival rates,which were determined by MTT assay.Sixty mice were randomly divided into six groups as follows: The drug groups mice were treated with rhoifolin for six day at the dose of 140,70,35mg/kg,respectively.The normal control group and the model control group took equivalent amount of distilled water by the same route.And mice in the positive control group were treated with 70mg/kg diammonium glycyrrhizinate.After the last administration,all groups except the normal control were administered with triptolide at dose of 0.625mg/kg by gavage to induce acute hepatic injury.Thereafter,the contents of ALT,AST in serum,the activities of SOD,MDA,GSH-Px and GST in the liver were measured and the hepatic histological changes were observed by optical microscope.Results: The cell survival rates of human L02 liver cells injured by triptolide and then treated with rhoifolin at the concentration of 75,150,300μg/ml were significantly increased.The contents of ALT,AST in serum were significantly decreased,the content of MDA in the liver was also significantly lowered,and the activities of SOD,MDA,GSH-Px and GST in liver were significantly improved after preventive treatment with rhoifolin at the dose of 140,70,35mg/kg.Rhoifolin can ameliorated the hepatic pathological changes.Conclusion: The protective effect of rhoifolin against hepatic injury induced by triptolide was significant in vitro and in vivo.
【Fund】: 国家自然科学基金资助项目(编号:30960495)
【CateGory Index】: R285
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【Citations】
Chinese Journal Full-text Database 4 Hits
1 SHU Ji-cheng,ZHANG Rui,ZHANG Wei,PAN Jing-hang,REN Xiao-jing,LIU Jian-qun(Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China);Flavonoids from Pteris multifida[J];Chinese Traditional Patent Medicine;2012-06
2 LIU Jian-qun,ZHANG Wei,ZHANG Rui,LI Qing,ZHAO Yuan(Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China) GAO Shu-liang(School of Preclinical Medicine,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China) XU Lai(School of Chemistry,Jiangxi Science and Technology Normal University,Nanchang 330013,China);Protective Effect of Pteris multifida against Triptolide-induced Hepatic Injury in Mice[J];China Pharmacy;2010-43
3 LIU Jian-qun1,HONG Qin1,ZHANG Wei1,SHI Min2,ZHANG Rui1,GU Bing3(1.Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Traditional Chinese Medicine,Jiangxi Nanchang 330004,China;2.Department of Preclinical medicine,Jiangxi University of Traditional Chinese Medicine,Jiangxi Nanchang 330004,China;3.Department of Pharmacy,Jiangxi Science and Technology Normal University,Jiangxi Nanchang 330013,China);Studies on the toxicity-reducing and activity-maintaining effects of triptolide combined with Pteris multifida[J];Chinese Journal of Hospital Pharmacy;2010-06
4 LIU Xiaohan1,CHEN Yonggang 2,LIN li3,CHEN Diling3,ZHUANG Manxian3(1.Guangdong Pharmaceutical College,Guangzhou 510006,China;2.Department of Pharmacy,the Third People's Hospital of Wuhan,Wuhan 430060 Hubei,China;3.School of Chinese Herbal Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006,China);Simultaneous Determination of Naringin and Rhoifolin in Exocarpium Citri Grandis by RP-HPLC[J];Traditional Chinese Drug Research and Clinical Pharmacology;2010-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LI Feng-yi1,LI Yun1(Director: XIAO Xiao-he2)(1Department of Integrate Traditional and Western Medicine,302 Hospital of PLA,Beijing 100039,China;2 PLA Institue of Chinese Meteria Medica,302 Hospital of PLA,Beijing 100039,China);Research status of herbal drug-induced liver injury[J];China Journal of Traditional Chinese Medicine and Pharmacy;2009-03
2 XUE Jing1,2,JIA Xiao-bin1,2,TAN Xiao-bin1,CHEN Yan1,ZHANG Lu-yong3(1Key Laboratory of New Drug Delivery System of Chinese Meteria Medica,the State Administration of Traditional Chinese Medicine,Jiangsu Provincial Academy of Chinese Medicine,Nanjing 210028,China;2Nanjing University of Chinese Medicine,Nanjing 210046,China;3China Pharmaceutical University,Nanjing 210009,China);Chemical constituents of Triptergium wilfordii Hook.f and its toxicity[J];China Journal of Traditional Chinese Medicine and Pharmacy;2010-05
3 Wang Hengbang1,Xu Jianhua1,Wen Caixia1,Huang Xiuwang1,Chen Yuanzhong21.Institute of Clinical Pharmacology,Fujian Medical University,Fuzhou 350004,China2.Fujian Institute of Hematology,Fuzhou 350004,China;Antitumor Effect of Triptolide in vitro and in vivo[J];Journal of Fujian Medical University;2007-04
4 CHEN Yong'an1,CHENG Lei2,MIAO Jieqiong1,et al (1.Changhai Hospital,The 2nd Military Medical University,Shanghai 200433,China; 2.Eastern Hepatobiliary Surgery Hospital,The 2nd Military Medical University,Shanghai 200433,China);Inhibitory Effects of Triptolide on Invasion and Metastasis of Human Liver Cancer MHCC97H Cells[J];Journal of Fujian University of Traditional Chinese Medicine;2012-02
5 LI Hua~(1,2),QIU Yun-liang~2,LI Min,TANG Na-ping~2,MA Jing~2,CHEN Chang-xun~1 (1.School of Chinese Herb,Shanghai University of Traditional Chinese medicine,Shanghai 201203; 2.National Shanghai Center For New Drug Safety Evaluation & Research,Shanghai 201203,China);Effect of triptolide on neonatal rat cardiac myocytes beating rates[J];World Clinical Drugs;2011-12
6 LIN Xian,XU Yu-juan,WU Ji-jun,TANG Dao-bang,CHEN Yu-long,WEN Jing,ZHANG Yan(Sericulture and Farm Produce Processing Research Institute,Guangdong Academy of Agricultural Sciences/ Guangdong Open Access Laboratory of Agricultural Produce Processing,Guangzhou 510610,China);Current status and prospect of Guangdong citrus processing industry[J];Guangdong Agricultural Sciences;2013-04
7 WAN Xiao-qi1,2,SONG Ping1,2,FENG Lei3,HONG Wei1,2,WU Cheng-zhen1,2,GE Heng-yi1,2(1.Key Laboratory of Fujian Colleges and University of Forest Ecological System Process and Management,Fuzhou,Fujian 350002,China;2.College of Forestry,Fujian Agriculture and Forestry University,Fuzhou,Fujian 350002,China; 3.College of Resources and Environment,Fujian Agriculture and Forestry University,Fuzhou,Fujian 350002,China);Study on immobilization of Tripterygium wilfordii cell[J];Journal of Fujian College of Forestry;2013-03
8 HAO Fu-ling;FANG Fang;LING Tie-jun;HU Feng-lin;SUN Qi-xiang;ZHANG Qian;WANG Xiao-gang;FANG Cong-bing;School of Horticulture, Anhui Agricultural University;Key Laboratory of Tea Biochemistry & Biotechnology, Ministry of Education, Anhui Agricultural University;Anhui Provincial Key Laboratory of Microbial Control;Key Laboratory of Forest Cultivation,State Forestry Administration, Institute of Forestry, Chinese Academy of Forestry;;Study on chemical constituents of Nerium indicum Mill[J];Journal of Anhui Agricultural University;2013-05
9 YAN Guohong;CHU Kedan;XU Wei;The First Affiliated Hospital,FUTCM;College of Pharmacy,FUTCM;;Determination of Triptolide and Sinomenine in Shuangteng Bitong Cataplasm by HPLC[J];Journal of Fujian University of Traditional Chinese Medicine;2013-05
10 Lu Baoping,Bai Juan,Jiang Ruoxia Hepatopathy Research Institute,Henan College of Chinese Medicine,Zhengzhou,Henan,China,450008;To Analyze and Approach Hepatic Injury Animal Model Induced by Drugs[J];Journal of Henan University of Chinese Medicine;2008-04
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Liu Q, Chen T, Chen H, Zhang M, Li N, Lu Z, Ma P, Cao X(Institute of Immunology, Second Military Medical University, Shanghai 200433, China);Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation[J];Academic Journal of Second Military Medical University;2004-09
2 Ding Hong, Peng Renxiu, Li Qixiong Department of Pharmacology, Basic Medical College, Hubei Medical University, Wuhan 430071,China;Influence of the Nitroglycerin Injected into Abdominal Cavity on NO Content in Heart, Brain and Kidney of Mice[J];JOURNAL OF HUBEI MEDICAL UNIVERSITY;2000-01
3 OU LiShanxi College of Traditional Chinese Medicine,Xianyang,Shanxi,China,712046;Progress in Study of Huguenot fern herb of Chinese herb[J];Guiding Journal of Traditional Chinese Medicine and Pharmacy;2008-03
4 LIN Ke xiong,WANG Chang zheng,QIAN Gui sheng (Department of Respiratory Deseases,Xinqiao Hospital,the Third Military Medical University,Chongqing 400038,China) [;Effects of triptolide on apoptosis of CD4~ + and CD8~ + T cells[J];IMMUNOLOGICAL JOURNAL;2000-01
5 LIU Zhihong,DAI Chunsun,LI Heng, LIU Dong,LIU Hong,LI Leishi Research Ins titute of Nephrology,Jingling Hospital,N anjing Univer sity School of Medicine,N anjing 210002;TRIPTOLIDE INHIBITS MCP-1 OVERPR ODUCTION IN HUMAN PROXIMAL TUBULA R CELLS INDUCED BY IFNγ AND TNFα COSTIMU LATION[J];Chinese Journal of Nephrology, Dialysis & Transplantation;2000-05
6 WT5”BX]ZHU Xuejun,LIU Zhihong,LIU Dong,CHEN Zhaohong,LI Leishi. Research Institute of Nephrology,Jinling Hospital,Nanjing University School of Medicine,Nanjing,210002;The effects of triptolide on cell growth and immunologic functions of human dendritic cells[J];Chinese Journal of Nephrology, Dialysis & Transplantation;2001-03
7 LI Heng,LIU Zhihong,DAI Chunsun,LIU Dong,LI Leishi Research Institute of Nephrology,Jinling Hospital,Nanjing University School of Medicine,Nanjing,210002;Triptolide down-regulates induced antigen-presenting cell function of human proximal tubular epithelial cells[J];Chinese Journal of Nephrology, Dialysis & Transplantation;2001-04
8 QIN Weisong, LIU Zhihong, ZENG Caihong, ZHENG Chunxia, JIA Zhong hui, WANG Shengyu, LI Leishi Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China;Therapeutic effect of triptolide on podocyte injury in passive Heymann nephritis[J];Chinese Journal of Nephrology,Dialysis & Transplantation;2007-02
9 ZHENG Chunxia, LIU Zhihong, SUN Jiping, ZENG Caihong, WANG Sheng yu, LI Leishi Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China;Therapeutic effect of triptolide on podocyte injury in nephrosis rats induced by puromycin aminonucleoside[J];Chinese Journal of Nephrology,Dialysis & Transplantation;2007-02
10 CHEN Zhaohong,LIU Zhihong,SUN Hua,YAO Genhong,QIN Weisong,L I Leishi Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China;Triptolid ameliorate podocyte injury induced by puro mycin aminonucleoside in vitro[J];Chinese Journal of Nephrology,Dialysis & Transplantation;2007-02
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