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《Pharmacology and Clinics of Chinese Materia Medica》 2014-04
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Study on anti-angiogenesis effect of arctigenin

He Fan;Sun Xiaoling;Su Yaliu;Sun Dong;Kang Tingguo;Liaoning University of Traditional Chinese Medicine;Liaoning Institute for Food and Drug Control;  
Objective: To observe the anti-angiogenesis effect of arctigenin in tumor tissue of tumor-bearing mice. Method: The S180 tumor-bearing mice was used to detect the anti-angiogenetic effect of arctigenin in vivo. Divide the tumor-bearing mice into five group: control group( blank solvent),5-fluorouracil( 40 mg/kg),arctigenin low,medium,high dose group( 40,80,160 mg/kg). Each group was continuously given corresponding medicine ten days by gavage,and then the mice were sacrificed by cervical dislocation. Weigh the tumor tissue and spleen,calculated inhibition rate and spleen index. The expression of tumor microvessel density( MVD) and vascular endothelial growth factor( VEGF) was detected by immunohistochemical staining. Result: Tumor growth and tumor tissue microvessel density( MVD) and VEGF expression was significantly inhibited by arctigeninin in a dose-dependent manner. When the concentrations of rctigenin were 40 mg /kg、80mg /kg、160 mg /kg,the inhibition rates on tumor were 23. 00 ± 13. 10%,40. 42 ± 12. 90% and 45. 67 ± 16. 15%,the microvessel density were 38. 25 ± 4. 53,32. 62 ± 3. 66 and 22. 75 ± 5. 28,the protein expression of VEGF were 75. 66 ± 8. 41%,70. 32 ± 5. 73% and 60. 66 ± 9.38%. Conclusion: Arctigenin can inhibit tumor growth and the microvessel density of S180 tumor-bearing mice,the expression of VEGF was also inhibited.
【Fund】: 辽宁省教育厅一般项目(L2012335);; 辽宁省科技厅自然科学基金项目(2013020171)
【CateGory Index】: R285.5
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