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《Pharmacology and Clinics of Chinese Materia Medica》 2014-05
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Sangjuyin attenuates acute lung injury induced by lipopolysaccharide in mice

Zhang Tianzhu;Yang Shihai;Zhang Jinglong;Changchun University of Chinese Medicine;Jilin Agricultural University;  
Objective: To determine the protective effect of Sangjuyin water extract on acute lung injury induced by lipopolysaccharide( LPS).Methods: The BABL / C mice were randomly allocated into control,LPS,dexamethasone( 2mg / kg) 、Sangjuyin water extracts( 6. 5 g / kg,13 g / kg). The bronchoalveolar lavage fluid( BALF) samples were analyzed for the concentration of numbers of neutrophilic,superoxide dismutase( SOD),methane dicarboxylic aldehyde( MDA),interleukin-6( IL-6) and tumor necrosis factor alpha( TNF-α),and The lung samples were taken for histologic evaluation and for determination of wet-to-dry( W / D) lung weight,The protein levels of p38 MAPK and NFκ-BP65 were detected by Western blot analysis. Results Pretreatment with Sangjuyin water extract( 6. 5 g / kg,13 g / kg) prior to the administration of intratracheal LPS significantly induced a decrease in lung wet weight / dry weight ratio,in total leukocyte number and neutrophil percent in the BALF,and in MDA activity of lung in dose-dependent manners,and in IL-6,the tumor neurosis factor-α( TNF-α) in the BALF and p38 MAPK and NFκ-BP65 protein in lung. These results showed that anti-inflammatory effects of Sangjuyin water extract( 6. 5 g / kg,13 g / kg)against the LPS-induced ALI.
【Fund】: 吉林省科学技术厅科技引导计划项目(200905110)
【CateGory Index】: R285
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