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《PHARMACOLOGY AND CLINICS OF CHINESE MATERIA MEDICA》 1996-01
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Protedve effects of API0134 on endothelial cells damaged by oxidatively modified low density lipoprotein

Wang Hongwei; Zhao Huayue; et al.(Tongji Hospital, Tongji Medical University. Wuhan 430030)  
rotective effects of API0134 on endothelial cells (EC) damaged by oxidatively modified low density lipoprotein(oxLDL) were studied. The results show, the contens of endothelin (ET) and MDA in the media of EC incubated withoxLDL were increased and the cGMP was decreased significantly, and the activity of SOD was inhibited. The effectof cytotoxicity of oxLDL can be eliminated by API0134. These data sugsest that APl0134 may protect EC against damageselicted by oxLDL.
【Fund】: 国家自然科学基金
【CateGory Index】: R285
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