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Pharmacokinetics of Puraria Flavanoids by New Technological Process

Du Lijun, Yu Lan, Chang Qi, Si Jianyong (Institute of medicinal plant PUMC and CAMS, Beijing 100094)  
By the experiment of pharmacokinetics, it was showed that the puraria flavanoids (PF) by the new pharmacceutical process should be test from the blood after 5~15 min orally in both rat and mouse, with Tmax 0.6~1.6h. The absolute bioavailability of PF(0.2g/kg) was 15.91%. It did the metabolism as the first order kinetics with the distribution as a bicompartment model. There was the time-concentration relationship of PF in vivo. The organs distributed by PF were mainly kidney,spleen, heart, liver and lung. The concentration of PF in the brain was lower but diminished slowly. The combining percentage of the plasma protein of PF was 45.22±1.28%, and the evacuation from the body was mainly by intestinal tract.
【CateGory Index】: R284.3
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