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《Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease》 2009-07
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Clinical Significance of Serum Adiponcetin in Hypoxic-ischemic Encephalopathy

Lu Zhiquan,Hou Yanming,Lin Dongyun,et al The Fifth Affiliated Hospital,Medical College of Jinan University(Qingyung 511500)  
Objective To explore serum adiponcetin levels in hypoxic-ischemic encephalopathy(HIE) and its clinical significance.Methods Ninety infants with HIE(slight pathologyical change group(n=30);medium pathologyical change group(n=30);serious pathologyical change group,n=30) and thirty healthy newborns were studied.The serum adiponcetin of HIE at 7th day,14th day and 30th day were tested.Results The levels of serum adiponcetin in infants with HIE were obviously lower than that in control group.It was(9.97±0.97) mg/L,(9.01±0.32) mg/L and(6.34±1.50) mg/L in slight pathologyical change group,medium pathologyical changes group and serious pathologyical change group,respectively(P0.01).There was significantly different in pathologyical change degrees with controls(P0.01).After treatment,the levels of serum adiponcetin was increased continuously at 7th day,14th day and 30th day.After treatment for 30 days,no significant differences were observed in the slight pathologyical change group and medium pathologyical changes group as compared with the levels of control group(P0.05).But there was still significantly different between the serious pathologyical change group compared with the levels of control group(P0.05).Conclusion The levels of serum adiponcetin were related to the degree of pathologyical change negatively.It was very important in determining the nervous system lesion and treatment of HIE.
【Fund】: 清远市科技计划基金项目(No.2008B0011)
【CateGory Index】: R722.1
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