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《Tumor》 1986-01
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HUMAN HEPATOCELLULAR CARCINOMA (HCC) MODEL IN NUDE MICE-ESTABLISHMENT OF HCC TISSUE MODEL AND ITS APPLICATION IN EXPERIMENT RESEARCH

Tang Zhao-you et al  
During 1979-1984, five surgical specimens of human hepatocellular carcinoma(HCC) were successfully transplanted into nude mice with background of Swiss nu/nu intwo models (LTNM_(1,2)) and Balb/cA nu/nu in three models (LTNM_(3,4,5)). The sucessfulrate for transplantation was 13.9% (5/36). Serial transplantation has been carried out in3, 7, 12~+, 9~+, 1 passages respectively. The take rates for serial passages were 97-98%with an average of 40 days for every passage. Results showed that both morphological andbiological characteristics, including cell type, grade of differentiation, alpha fetoproteinand isoferritin secretion were all the same as that shown in the original HCC. These modelshave been used in studies of tumor markers (AFP, isoferritin), radioimmunodetection(antibodies against AFP, isoferritin and transferrin receptor), screening of chemothera-peutic agents for HCC, and providing tumor tissue to establish human HCC model in nuderats, all of thses being found to be of great value in experimental research.
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【References】
Chinese Journal Full-text Database 8 Hits
1 Bai Shaohuai;Zhang Xuanbo;Xie Congyi;Hou Shixiang;Zhang Zhirong;Liao Gongtie Center of Lab Animals Department of Pharmeceutics;A Model off Orthotopic Transplantation of Human Hepatoma Established in Nude Mice Tumor Inhibition Studies[J];;1993-04
2 Fu Hong Mei, Lu Yuan.Department of Clinical Laboratory, Hua Shan Hospital, Shanghai Medical University, Shanghai 200040;Analysis of N liked sugar chain structures of ALP from human liver cancer tissue.[J];SHANGHAI JOURNAL OF MEDICAL LABORATORY SCIENCES;1999-03
3 Zhu Yuanxi; Hao Xishan; Sun Hut; et al. (Tianjin Cancer Institute Hospital,Tianjin 300060) [;Experimental Study on the Treatment of Human Hepatocarcinoma in Nude Mouse by Beta-carotene Combined with Adriamycin[J];CHINESE JOURNAL OF CLINKAL ONCOLOGY AND REHABILITATION;1999-05
4 LI Yan, TANG Zhaoyou, YE Shenglong, LIU Yinkun, CHEN Jie, XUE Qiong, HUANG Xiaowu, CHEN Jun, BAO Weihua, YANG Jiong, GAO Dongmei. Liver Cancer Institute and Zhong Shan Hospital of Fudan University, Shanghai, 200032, China;Establishment of human hepatocellular carcinoma cell line with spontaneous pulmonary metastasis through in vivo selection[J];National Medical Journal of China;2002-09
5 Ouyang Nengtai Zhou Muheng Dong Jun ( Department of Pathology );DISTRIBUTION OF BASEMENT MEMBRANE COMPONENT IN HUMAN HEPATOCELLULAR CARCINOMA AND ITS XENOGRAFT IN NUDE MICE[J];;1992-01
6 Yao Wei-qiang et al;A STUDY ON THE GROWTH KINETICS OF HUMAN HEPATOCELLULAR CARCINOMA IN NUDE MICE AND ITS RELATION TO AFP VALUE[J];Tumor;1988-02
7 Yu Zhu-yuan et al Zhong-Shan Hospital, The First Medical College, Shanghai;CYTOSTATIC EFFECT OF VCR--IgG CONJUGATE TO HEPATOMA[J];Tumor;1989-04
8 Tang Zhao-you;Liu Kang-da;Fan Zhen Liver Cancer Institute, Shanghai Medical University, Shanghai;TARGETING THERAPY OF HEPATOCELLULAR CARCINOMA——EXPERIMENTAL AND CLINICAL STUDIES[J];Tumor;1990-06
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Ma Zeng-chen Tang Zhao-you, Yu Ye-qin, Lin Zhi yingLiver Cancer Research Unit, Zhongshan Hospital, Shanghai First Medical College, Shanghai;STUDIES IN EXPERIMENTAL HEPATOMA MODELS FROM CLINICAL VIEW POINT I. COMPARISONS OF RAT HEPATOMA MODELS AND PRELIMINARY OBSERVATION OF TRANSPLANTA-BLE HUMAN HEPATOMASIIN NUDE MICE[J];Chinese Journal of Cancer;1983-04
2 Xu Yuan-ding;Ying Yue-ying;Wu Ai-juan Department of Pathology, Shanghai First Medical College;EXPERIMENTAL PATHOLOGICAL STUDY ON LIVER CARCINOGENESIS[J];Tumor;1982-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHAI Bao Jin, WU Feng, SHAO Ze Yong, HU Kai, ZHAO Chun Liang, WANG Zhi Biao Department of Biomedical Engineering, Institute of Ultrasound and Engineering in Medicine, Chongqing University of Medical Science, Chongqing,400016, P.R.China;Establishment of In Vivo Adriamycin induced Multidrug Resistance Models of Subcutaneous and Hepatic Transplanted Human Liver Cancer in Nude Mice[J];Chinese Journal of Cancer;2004-08
2 Department of Pathology Wang Luoquan, et al;EXPERIMENTAL STUDY OF AFB1-INDUCED HEPATOCARCINOGENESIS IN RATS[J];;1989-01
3 Tao Wenzhao, et al Department of Pathological Anatomy;PATHOLOGICAL STUDY OF NONCIRRHOTIC HEPATOCELLULAR CARCINOMA: ITS ETEOLOGY AND HISTOGENESIS[J];Academic Journal of Second Military Medical University;1984-02
4 Tao Wenzhao, et al Department of pathological Anatomy;PATHOLOGICAL OBSERVATIONS ON THE ENZYME-LABELING IMMUNO-FETOPROTEIN IN HUMAN NONCIRRHOTIC LIVER CANCER AND PERI-CANCER TISSUE[J];Academic Journal of Second Military Medical University;1985-01
5 Tao wenzhao, et al (Department of pathological Anatomy);PRECANCEROUS LESIONS AND HISTOGENESIS OF RAT HEPA-TOCELLULAR CARCINOMA INDUCED BY AFLATOXIN B_1[J];Academic Journal of Second Military Medical University;1988-02
6 Li Lie Lany zhiren Department of Pathology;The Developing Observation of Liver Carcinogenesis of The Rats[J];Academic Journal of Guangzhou Medical College;1988-04
7 Chen Bingyao;Qin Lirang;Lei Jianbao, (Huazhong Agricultural University, Wuhan, China);STUDIES ON THE DETOXIFICATION EFFECT OF PAEONIAE ALBA TO ACUTE AFIATOXICOSIS OF BEIJING DUCKLING[J];Journal of Huazhong Agricultural;1988-01
8 Shen Lulong, et al.;THE ULTRASTRUCTURAL CHANGES OF LIVER DURING CARCINOGENESIS IN DIETHYLNITROSAMINE-FED RATS[J];;1987-03
9 Zhou Guangxing;Yang Junhua;Zhao Weizhi;Peng Songlin ent of Laboratory Animal Science,Shanghci Medical University,Shanghai);AN EXPERIMENTAL MODEL ON DIETHYLNITROSAMINE HEPATOCARCINOGENESIS IN NEWBORN WISTAR RATS[J];ACTA ATADEMIAE MEDICINAE SHANGHAI;1994-02
10 Wang Taiyi (Laboratory Animal Centre, China Medical University, Shenyang);Establishment of Transplanted Tumor Model of Human Laryngeal Carcinoma in Nude Mice and Studies on its Partial Biological Characteristics[J];Acta Laboratorium Animalis Scientia Sinica;1993-02
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Ma Zeng-chen Tang Zhao-you, Yu Ye-qin, Lin Zhi yingLiver Cancer Research Unit, Zhongshan Hospital, Shanghai First Medical College, Shanghai;STUDIES IN EXPERIMENTAL HEPATOMA MODELS FROM CLINICAL VIEW POINT I. COMPARISONS OF RAT HEPATOMA MODELS AND PRELIMINARY OBSERVATION OF TRANSPLANTA-BLE HUMAN HEPATOMASIIN NUDE MICE[J];Chinese Journal of Cancer;1983-04
2 ZHANG Hong xin*,GUO Wei ping,WANG Zhi min,et al Department of Interventional Radiology,Tangdu Hospital,the Fourth Military Medical University,Xi′an 710038,P R China;Establishment and characteristics of human multidrug resistant hepatocellular carcinoma cell line(7721/Adm)[J];CHINESE JOURNAL OF CANCER;2000-08
3 CHEN Xiao-ming LUO Peng-fei HU Jing-qin SHAO Pei-jian ZHOU Zhejian FU Li TANG Yi YU Yan-xin(Intervenenlional Department of Radiology,Poople,s Hospital of Guangdong ProvincE, Guanzhou 510080 );DELAYED ADVERSE REACTION OF LIVER AFER LIPIODOL-TRANSCATHETR ARTERIAL CHEMoEMBOLIZETION(Lp-TAE)FOR THE TREATMBNT OF HEpATOCELLULAR CARCINOMA[J];CHINESE JOURNAL OF CANCER;1994-01
4 DUAN Xiaoxian; QIN Liuliang;QIN Guo zhong;YAN Ruiqi(Department of pathology,Guangxi Cancer Institute,Nanning 530021)(Cancer Institute,Sun Yat-sen University of Medical Sciences,Guangzhou 510060);SHORT TERM EXPERIMENTAL ANIMAL MODEL OF HEPATOCEARCINOGENESIS INDUCED BY SINGLE DOSE of AFLATOXIN B1 IN RATS[J];CHINESE JOURNAL OF CANCER;1996-01
5 LI Yi-xuan,LIU Min,LI Xin,TANG Hua(Tianjin Life Science Research Center and Basic Medical School,Tianjin Medical University,Tianjin 300070,China);The Genes Associated with Geldanamycin Inhibiting Replication of Herpes Simplex Virus Type 1[J];Chinese Journal of Virology;2008-03
6 Qiao Jian 1 Yan Ziying 2 Gong Huiyu Wang Hailin Qian Zhenchao 1 Hou Yunde (National Laboratory of Molecular Virology and Genetic Engineering, Institute of Virology, CAPM, Beijing 100052);IN VIVO EBV-BASED VECTOR TARGETED INTO RAT HEPATOCYTES AND EXPRESSED BY RECEPTOR- MEDIATED GENE DELIVERY[J];CHINESE JOURNAL OF VIROLOGY;1997-04
7 LI Jing1,2,JIANG Zheng3,CHEN Li1,SUN Hai-bo1(1.Department of Gastroenterology,First Affiliated Hospital,Liaoning Medical University,Jinzhou 121000,China;2.First Hospital,Jilin University,Changchun 130021,China;3.Department of Orthopaedics,Second Hospital of Jinzhou City,Jinzhou 121003,China);Effect of down-regulating survivin expression by RNAi on growth suppression and promotion on apoptosis of human hepatocellular carcinoma cells[J];Journal of Jilin University(Medicine Edition);2009-01
8 Wu Bing-quan;Heterotransplantation of Human Colonic Mucinous Adenocarcinoma to Nude Mice[J];;1982-03
9 Jiang Jinxing,et al Department of Toxicology;THE STUDY OF EXPERIMENTAL PATHOLOGY OF AFLATOXIN B_1-INITIATED HEPATOCARCINOGENISIS IN RATS[J];;1992-03
10 Lihua Wang~1 Xiaohu Zhang~1 William L. Farrar~2 Xiaoyi Yang~(1,2,3) 1 Basic Research Program, SAIC-Fredefick.National Cancer InstituteFrederick.Frederick.USA. 2 Cytokine Molecular Mechanisms Section.Laboratory of Molecular Immunoregulation.Division of Basic Sciences,National Cancer Institute-Frederick,Frederick.USA.;Transcriptional Crosstalk between Nuclear Receptors and Cytokine Signal Transduction Pathways in Immunity[J];中国免疫学杂志(英文版);2004-06
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Xin-wang,YANG Jian-yi,LI Li,DU Sheng-jia(Shanxi Medical University,Taiyuan 030001,China);Effect of β-carotene on Genetic Damage Induced by Mitomycin-C in Bone Marrow Cells of Mice[J];Carcinogenesis,Teratogenesis & Mutagenesis;2008-04
2 Liu Hu,Ye Sheng -Long ,Li Wen-Chang ,Li Yan,Liu Yin-Kun,Qin Lun-Xiu,Qiu Shuang -Jian,Sun Rui-Xia,Chen Jie,Tang Zhao-YouLiver Cancer Institute /Zhongshan Hospital,Fudan University,Shanghai,200032,P.R.China;Quantitative Analysis of Expression of TEY1 Gene in Liver Cancer Cells with Different Metastatic Potential[J];Chinese Journal of Cancer;2003-06
3 PENG Zhihong~1, TANG Bo~2, YANG Jianmin~1, SI Suihai~1, CHEN Wensheng~1, FANG Dianchun~1, LUO Yuanhui~1 (~1Gastroenterology Research Center, ~2Department of General Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Effects of metastasis suppressor gene KAI1 on adhesion forces of MHCC97-H hepatocellular carcinoma cells with high metastatic potential[J];Acta Academiae Medicinae Militaris Tertiae;2005-23
4 QUAN Xian-yue1, XIE Wei1, ZHANG Xue-lin2, SUN Xi-Jie1, ZHU Xing-li1, YAN Zheng1, LIANG Wen1 1Imaging Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China; 2Diagnostic Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;Modification of the method for preparing rabbit liver VX2 tumor model and its MRI findings[J];Journal of Southern Medical University;2006-06
5 LIU Ying,ZHANG Rui-jun,WU ZHi-wei,SHI Ling (Institute of Laboratory Animal Science,Medical Institute of Gansu Province,Lanzhou,Gansu,730050,China);Advance in Animal Models of Transgenic Diseases[J];Progress in Veterinary Medicine;2006-12
6 LIN Xi, HUANG Xiu\|wang, KE Dan\|ru, et al (Institute of Clinical Pharmacologe, Fujian Medical University, Fuzhou\ 350004, China);Cytotoxic Effects of Transferrin-Methotrexatum Conjugates to Cultured Hepatocellular L-02 Cells and Hepatocellular Carcinoma Bel 7404 Cells[J];Journal of Fujian Medical University;2001-01
7 Zhou Denan,Gan Youquan,Wu Yingde,et al(Guangxi Cancer Institute Nanning 530021);A STUDY ON THE PREPARATION OF 125 I Ab AFP[J];ACTA ACADEMIAE MEDICINAE GUANGXI;1996-04
8 CHEN Liangdong,LI Yan,ZHENG Fang,LI PengchengDept.of Oncology,Zhongnan Hospital of Wuhan University & Cancer Center of Wuhan University,Wuhan 430071,China;Study on the Intraperitoneal Chemotherapy with Hydroxycamptothecin for the Treatment of Peritoneal Carcinomatosis in Mice[J];Medical Journal of Wuhan University;2008-06
9 Wang Lei1,Li Xiaopei2,Xu Junzheng1,Gao Taixin1,Xu Cunshuan1,2(1.Key Laboratory for the Research of Cell Differentiation and Regulation,Xinxiang 453007,Henan China;2.College of Life Science,Henan Normal University,Xinxiang 453007,Henan China);The Changes of Hepatic Histology in Liver Cancer Modeding of the Rat[J];Henan Science;2009-04
10 LONG Ya-hong,LI Yun-chun,MI Yan-xia. Department of Nuclear Medicine,West China Hospital,Sichuan University,Chengdu 610041,China;Effect of ~(131)I-labeled Recombinant Human Tumor Necrosis Factor-α on the Nude Mice Bearing Human Hepatoma[J];Journal of Sichuan University(Medical Science Edition);2009-05
China Proceedings of conference Full-text Database 1 Hits
1 ;Progress in cellular and molecular biology research in recurrence and metastasis of hepatocellular carcinoma[A];[C];2007
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 TANG ZHAOYOU, MA ZENGCHEN, XUE QIONG, LIN ZHIYING(Liver Cancer Besearch Unit, Zhong Shan Hospital, Shanghai First Medical College, Shanghai)YING YUEYING, Xu YUANDING, SUN LINGSHAN, YUAN XINHUA(Department of Pathology, Faculty of Basic Medical Sciences, Shanghai First Medical College, Shanghai);TRANSPLANTATION OF HUMAN HEPATOCELLULAR CARCINOMA IN NUDE MICE Ⅰ. ESTABLISHMENT OP MODEL AND ITS SEROLQGICAL AND MORPHOLOGICAL FEATURES[J];;1982-01
2 MA ZENGCHEN, XUE QIONG ,TANG ZHAOYOU(Liver Cancer Research Unit, Zhong Shan Hospital, Shanghai First Medical College, Shanghai)XU YUANDING(Department of Pathology, Faculty of Basic Medical Sciences, Shanghai First Medical College, Shanghai);EXPERIENCE IN REPRODUCTION OF NUDE MICE BY HETEROZYGOTE[J];;1982-06
3 CHIANG CHIA-MO;JI WEN-XING;SUN LAN-YING;XU YUNG-HUA Shanghai Institute of Cell Biology, Academia Sinica.;STUDIES ON A TRANSPLANTABLE RAT HEPATOMA BERH-2 Ⅰ.THE ESTABLISHMENT OF THE TUMOR LINE AND ITS MORPHOLOGY,ULTRASTRUCTURE AND α-FETOPROTEIN PRODUCTION[J];Acta Biologiae Experimentalis Sinica;1978-01
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