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《Tumor》 2002-06
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The mechanism of coixenolide-induced apoptosis in human cervical cancer cells

HAN Suxia, ZHU Qing, DU Beiru,et al.(Department of Oncology, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China)  
Objective To study the mechanism of coixenolide induced apoptosis. Methods Morphological study, DNA gel electrophoresis, flow cytometry and fluorescin labeled Annexin V to detect apoptosis, RT PCR to detect the gene related with apoptosis. Results Human cervical cancer HeLa cells treated with coixenolide induced cell cycle arrest at G 2M phase, leading to apoptosis. The morphology of HeLa cells showed nuclear chromatine condensation and fragmentation. Typical ladder pattern of DNA fragmentation was observed. Transcription of Fas gene was enhanced, but FasL gene was lowered. Annexin labeling results revealed the co existense of cell apoptosis and necrosis in coixenolide treated HeLa cells. Conclusion Coixenolide induces apoptosis and necrosis of human cervical cancer. The inducton of apoptosis may berelated to expression of Fas and FasL.
【CateGory Index】: R737.33
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