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《Tumor》 2005-05
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Enhanced expression of peroxisome proliferator-activated receptor γ in liver cancer

Guo Minglei, Li Jingjun, LI Hongnian, WAN Da fang, Gu Jianren. (Department of Biochemistry , Shanghai Cancer Institute,Shanghai 200032,China)  
Objective To investigate whether the PPAR7 has high expression and mutation in liver cancer. Methods semi-quantitative RT-PCR,Western blot, FISH and PCR-SSCP method. Results PPARγ was over-expressed in matched HCC and non-cancerous tissues (8/14 by semi-quantitative RT-PCR and 9/15 by Western blot). Immunochemical staining demonstrated that PPAR7 was located in cytoplasmic in all non-cancerous liver in contrary to the nuclear localization in some of HCC cell. In addition, there was no mutation in the exon3 and exon5 of PPAR7 in 34 paired HCC tissues. Conclusion It suggested that PPARγ may be involved with HCC development.
【Fund】: 国家重点基础研究发展规划项目(编号:20048704)
【CateGory Index】: R735.7;
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