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《Tumor》 2008-02
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The expression of multi-drug resistance gene in breast cancer stem cells and its significance

LI Zhi,LIU Chun-ping,HE Yan-li,ZHANG Jing-hui,HUANG Tao (Department of Breast and Thyroid Surgery, Union Hospital,Huazhong University of Science and Technology,Wuhan 430022,China)  
Objective:To detect the expression of multi-drug resistance genes MDR 1 and BCRP in breast cancer stem cells and differentiated cells as well as discuss their clinical significance. Methods:The breast cancer stem cells were separated from human primary breast cancer tissue and MCF-7 cells by flow cytometry-based selection on freshly isolated cells. The expressions of MDR 1 and BCRP in different subsets of cells was measured by real-time PCR. Results:Compared with breast cancer differentiated cells, the expressions of MDR 1 and BCRP in breast cancer stem cells were significantly higher (P0.01), and the proportion of stem cells markedly increased after chemotherapy (P0.01). Conclusion:Compared with breast cancer differentiated cells, breast cancer stem cells have stronger drug-resistance against chemotherapy via over-expression of multidrug resistance genes, which is one of the key factors for failure of chemotherapy and recurrence of breast cancer.
【Fund】: 国家自然科学基金资助项目(编号:30571798);; 湖北省“十一五”重大科技攻关项目(编号:2006AA301A05)
【CateGory Index】: R737.9
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Chinese Journal Full-text Database 10 Hits
1 LI Jia;JIN Cong-guo;ZOU Tian-ning;CHEN Xiao-qun;LIU Xin;WANG Xi;WANG Xi-cai;Tumor Research Center,Yunnan Tumor Hospital;Dept. of Mastopathy,Yunnan Tumor Hospital;;Comparison of Side Population Cells Level and Biological Characteristics between Human Breast Cancer Tissue and MCF-7 Cells[J];Journal of Kunming Medical University;2015-07
2 LI Xun,YANG Shun-e,GUAN Ya-qun (Department of Chemotherapy, Affiliated Tumor Hospital Xinjiang Medical University,Urumqi Xinjiang 830011,China);Relation of expression of survivin and BCRP gene in prediction of response to chemotherapy in metastatic breast cancer[J];China Oncology;2009-04
3 YANG Guohua,XUE Fangqing,CHEN Xiaogeng(Department of Oncology Surgery,Fujian Provincal Hospital,Fuzhou 350001,China);Prognostic value of different amounts of cancer stem cells in different molecular subtypes of breast cancer[J];Chinese Journal of General Surgery;2011-11
4 HE Yu-qi1,LING Xian-long2,YU Jin-qiu1,LI Shi-wei2,ZHOU Yuan2,LI Xin-qiang2,YAN Bin2(1.Department of Internal Medicine,531 Hospital of People's Liberation Army,Tonghua 134002,China;2.Department of Gastroenterology,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Study on the relationship between mitochondrial DNA injury and multidrug resistance of human hepatocellular carcinoma[J];Tumor;2009-09
5 CHEN Ying-xin, LI Lian-hong, YANG Xiao-li, WANG Bo, WANG Li-xia (Center of China-Japan Clinical Pathology, Dalian Medical University, Dalian 116027, China);Expressions of CK5,CK8 and BCRP in the lesions of mammary gland and its significance[J];Tumor;2010-06
6 LOU Ying, SHEN Kun-wei (Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025,China);Prospect of breast cancer stem cells:from basic research to clinic application[J];Tumor;2010-06
7 Zhou Xin1,Wu Chengyi2 1.Department of Breast Surgery,Chongqing Cancer Institute,Chongqing 400030,China;2.Department of Endocrine and Breast Surgery,The First Affiliated Hospital,Chongqing Medical University;Relationship of CD44~+/CD24~(-/low) with Responsiveness of Breast Cancer to Anthracycline-based Chemotherapy[J];Cancer Research on Prevention and Treatment;2012-08
8 HAN Yuzhen1,SANG Jing2,LU Zenghua3,ZHU Yuhong3 (1.Department of Pathological Sciences,Binzhou Medical University,Binzhou,Shandong 256603,China;2.Department of Pathology,the Central Hospital of Tai'an,Tai'an,Shandong 271000,China;3.Department of Pathology,the Affiliated Hospital,Binzhou Medical University,Binzhou,Shandong 256603,China);Clinicopathologic significance of breast cancer stem cells concerning their content and expression of drug resistance related proteins[J];Chinese Journal of General Surgery;2012-11
9 GENG Xuan 1 GENG Dan 2 JING Shi-bing 3 WANG Yan-qing 4 LIU Qing-feng 5 1.Second Clinical Medical College of Dalian Medical University,Dalian 116044,China;2.Department of Oncology,People's Hospital of Liaoning Province,Shenyang 110013,China;3.Department of Pathology,People 's Hospital of Liaoning Province,Shenyang 110013,China;4.Second Department of General Surgery,People's Hospital of Liaoning Province,Shenyang 110013,China;5.Department of Endocrine Surgery,People's Hospital of Liaoning Province,Shenyang 110013,China;Study of expression of ABCG2 in breast cancer and pericarcinomatous tissue and its clinical correlation[J];China Modern Medicine;2013-21
10 YANG Chao;CUI Zhichao;GUO Qingjun;LIU Yunjiang;WANG Shijie;Department of Breast Center,the Fourth Hospital,Hebei Medical University;Department of the First mammary,the People ’s Hospital of Tang Shan;Department of Educational Administration,Hebei Medical University;Department of Endoscope,the Fourth Hospital,Hebei Medical University;;The activity of special CTLs in diminishing CD55~(high) subgroup in human breast cancer MCF-7 cells[J];Chinese Journal of Cellular and Molecular Immunology;2013-11
Chinese Journal Full-text Database 10 Hits
1 LI Dao-wang,MA Cheng-ming,WANG Hong-qun,YANG Feng(Department of Surgery,the Traditional Chinese Medical Hospital of Taihu County,Taihu,Anhui Province 246420);Expression of p53,ER,and PR in breast cancers and its clinical and prognostic significance[J];Anhui Medical and Pharmaceutical Journal;2008-10
2 Liu Jian Yong1, Zhang Chun Yan2, Zhao Yin Nong1, Tang Kai2, Zhang Li Tu2, Li Ting1 1.Department of Surgery, Affiliated Cancer Hospital of Guangxi Medical University,Nanning,Guangxi, 530021,P.R.China 2.Department of Cell and Molecular Biology,Affiliated Cancer Hospital of Guangxi Medical University, Nanning,Guangxi,530021, P.R.China;Study of Anti Breast Cancer Activity of Tumor Infiltrating Lymphocytes Affected by Dendritic Cells[J];Chinese Journal of Cancer;2003-10
3 Yu Ping1, Xiao Ning-Xin2, Chen Yan-Ping3 1.Department of Mastopathy, Jiangmen Wuyi Hospital of Traditional Chinese Medicine,The Sixth Affiliated Hospital of Jinan University Medical College, Jiangmen,Guangdong,529030, P.R.China 2.Department of Pathology, Jiangmen Peoples Hospital, Jiangmen,Guangdong,529050, P.R.China 3.Department of Pharmacy, Jiangmen Wuyi Hospital of Traditional Chinese Medicine,The Sixth Affiliated Hospital of Jinan University Medical College, Jiangmen,Guangdong,529030, P.R.China;Expression of P-Glycoprotein and Lung Resistance Protein in Breast Carcinoma and Its Relationship with Prognosis[J];Chinese Journal of Cancer;2003-12
4 Zhang Shu-Qun,Qiang Shui-Yun,Yang Wen-Bin,Jiang Jian-Tao,Ji Zong-Zheng Department of Oncology,The Second Hospital,Xian Jiaotong University,Xian,710004,P.R.China;Expression of Survivin in Different Stages of Carcinogenesis and Prog ression of Breast Cancer[J];Chinese Journal of Cancer;2004-06
5 LI Bao-Jiang,ZHU Zhi-Hua,WANG Jun-Ye,HOU Jing-Hui,ZHAO Jin-Ming,ZHANG Peng-Yuan,YAO Guang-Yu,WANG Xi,LONG Hao,YANG Ming-Tian,RONG Tie-Hua Department of Thoracic Surgery,Cancer center,Sun Yat-sen University,Guangzhou,Guangdong,510060,P.R.China;Expression Correlation of Ki67 to P53,VEGF,and C-erbB-2 Genes in Breast Cancer and Their Clinical Significances[J];Chinese Journal of Cancer;2004-10
6 XU Hong1,2, MAO Yi-Xiang1,2, ZHANG Xue-Guang2, WANG Qing-Cai11. Department of Oncology, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu, 215006, P. R. China 2. Department of Immunology, Institute of Biotechnology, Soochow University, Suzhou, Jiangsu, 215007, P. R. China;Influence of Intravenous Chemotherapy on Cellular Immunity in Patients with Advanced Digestive Tract Cancer[J];Chinese Journal of Cancer;2008-04
7 Jian Chen 1,2,Zeng-Liang Chen1 1.School of Medicine, Zhejiang University, Hangzhou,Zhejiang 310058, P. R. China 2.Zhejiang Medical College, Hangzhou,Zhejiang 310053, P. R. China;Technology update for the sorting and identification of breast cancer stem cells[J];Chinese Journal of Cancer;2010-03
8 Cuan Jian Chen Jie Cao Yufeng Cao Jinling Gao Jie Zhao He Department of Pathology,Peking Union Medical College Hospital,CAMS&PUMC,Beijing 100730,China;Expression and signiticance of SVV protein in breast adenosis,adenoma,and carcinoma[J];Oncology Progress;2009-06
9 DONG Hua-ying,WU Cheng-yi,CHEN Yuan-wen(Department of Endocrine Surgery,Frist Affiliated Hospital,Chongqing Medical University, Chongqing 400016,China);Isolation,culture and identification of microspheres in breast cancer stem cells after neoadjuvant chemotherapy[J];Journal of Jilin University(Medicine Edition);2011-01
10 DU Chang-zheng, LI Hui-ping, HOU Kuan-yong, LI Qiang, ZHAO Hong-mei, WANG Mo-pei Department of Oncology Chemotherapy Department of General Surgery, Peking University Third Hospital, Beijing 100083, China;Expression of epidermal growth factor receptor-2 in Chinese breast cancer patients:a meta-analysis[J];Journal of Peking University(Health Sciences);2006-02
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 LIU Jian,TAO Ya-jun,CHEN Ying-jie,YANG Ru-hong(Department of Pathology,Medical College of Dalian University,Dalian 116622,China);Expression and clinical significance of p53,C-erbB-2,VEGF-C and nm23 in breast cancer[J];Journal of Dalian Medical University;2012-05
2 YANG Guohua,XUE Fangqin,CHEN Xiaogeng Department of Cancer Surgery,Provincial Clinical College,Fujian Medical University,Fuzhou 350001,China;Expression of MDR1 gene in cancer stem cells in breast cancer tissues of different molecular subtypes[J];Journal of Southern Medical University;2012-11
3 Zhang Zong-lin(Linyi City,Shandong Province,People's Hospital,Department of Pharmacy,Linyi 276000,China);Containing Anthracycline Cardiac Toxicity in Breast Cancer Patients with Chemotherapy[J];Chinese Journal of Medicinal Guide;2013-08
4 SHI Wei-jian1),WANG Yu-zhi2),LI Quan-yong1),PAN Cheng-xin3),MI Xian-jun4) 1) Department of Oncology,Zhongshan Boai Hospital Affiliated to Southern Medical University,Zhongshan 528403,China;2) Department of Prevention and Health Care,Zhongshan Boai Hospital Affiliated to Southern Medical University,Zhongshan 528403,China;3) Department of Breast Surgery,Zhongshan Boai Hospital Affiliated to Southern Medical University,Zhongshan 528403,China;4) Department of Pathology,Zhongshan Boai Hospital Affiliated to Southern Medical University,Zhongshan 528403,China;Relationship of the expression of the survivin protein with C-erbB-2 gene and drug-resistance-associated genes in breast cancer tissues[J];Journal of Chinese Practical Diagnosis and Therapy;2011-12
5 ZENG Ling-rui;HAN Yu-zhen;MA Ying-lu;LI Wen-xing;Department of Pathology,Affiliated Hospital of Binzhou Medical College;Department of Pathology,Binzhou Medical University;Department of Thyroid and Breast Surgery,Affiliated Hospital of Binzhou Medical College;;Comparative study on Wnt,Notch signaling pathway molecules in primary breast cancer and matched lymph nodes metastasis stem cells[J];Chinese Journal of Clinical and Experimental Pathology;2014-09
6 WANG Yiwen;WANG Gaiping;GENG Xiaofang;QIAN Dan;ZHANG Jihong;HE Tingting;XU Cunshuan;College of Life Science,Henan Normal University;State Key Laboratory Cultivation Base for Cell Differentiation Regulation,Henan Normal University;Henan Engineering Laboratory for Bioengineering and Drug Development,Henan Normal University;;Role of 5 Signaling Pathways in Regulating NIH3T3 Cell Cycle[J];Journal of Henan Normal University(Natural Science Edition);2015-03
7 LI Pei-kun,GENG Xiao-ping Department of Surgury,Second Affiliated Hospital of Anhui Medical University,Hefei 230601,P.R.China;Recent genomic research and development of hepatocarcinoma multidrug resistance[J];Chinese Journal of Cancer Prevention and Treatment;2012-12
8 Xian-Long Ling~*,Yu-Qi He,Yuan Zhou,Lei Wen (Department of Gastroenterology,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);P-glycoprotein Mitochondrial Translocation on Multidrug Resistance in the Mitochondrial DNA-depleted Cells[J];Chinese Journal of Cell Biology;2011-01
9 Zhao Jin,Li Hongxia,Zhang Sumei.Department of Obstetrics and Gynecology,Affiliated Beijing Shijitan Hospital of Capital Medical University,Beijing 100038;The research for mitochondrial DNA mutation in ovary cancer Taxol-resistant cell line[J];Progress in Obstetrics and Gynecology;2012-06
10 LIU Cong,YUE Yong-hua,HAO Xu-liang.(Research Institute of Materia Medica Formulas,Traditional Chinese Medicine Institute of Shanxi Province,Taiyuan 030012,China);Progress of Research into the Pathogenesis of Breast Hyperplasia[J];Medical Recapitulate;2012-05
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