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《Tumor》 2010-06
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Expressions of CK5,CK8 and BCRP in the lesions of mammary gland and its significance

CHEN Ying-xin, LI Lian-hong, YANG Xiao-li, WANG Bo, WANG Li-xia (Center of China-Japan Clinical Pathology, Dalian Medical University, Dalian 116027, China)  
Objective:To investigate the expressions of cytokeratin 5 (CK5), CK8 and breast cancer resistance protein (BCRP) in the benign and malignant lesions of human mammary gland and their significance.Methods:Eighty-nine samples of human mammary gland tissues were collected in this study. Immunohistochemical technique was used to detect the expressions of CK5, CK8 and BCRP. The correlation of their expressions with the differentiation of the mammary gland tissues with benign and malignant hyperplasia was analyzed. Results:The positive expressions of CK5and CK8 gradually decreased but the expression of BCRP increased step by step in normal mammary gland, hyperplasia, atypical hyperplasia, ductal carcinoma in situ, and infiltrating ductal carcinoma tissues. The expressions of CK5 and CK8 were markedly higher in benign hyperplasia tissues (hyperplasia plus atypical hyperplasia) than those in breast cancer tissues (ductal carcinoma in situ plus infiltrating ductal carcinoma) (P0.01). In contrast the expression of BCRP was significantly higher in breast cancer tissues than that in breast tissues with benign hyperplasia (P0.01). In infiltrating ductal carcinoma, CK5 was mainly expressed in basal lamina not infiltrated by tumor cells. There was no or little expression of CK5 in cancer cell. Contrary to CK5, CK8 was mainly expressed in cancer cells and was not expressed in basal lamina. There was 66.7% infiltrating ducal carcinoma displayed CK5-/CK8+ phenotype. Conclusion:The expression patterns of CK5, CK8 and BCRP were different in various breast tissues. Combined detection of the three proteins may be helpful for the pathological diagnosis of lesions of mammary gland.
【Fund】: 辽宁省博士科研启动、自然科学基金资助项目(编号:20042136)
【CateGory Index】: R737.9
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