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《TUMOR》 1998-06
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A PHASE Ⅲ CLINICAL STUDY OF PACLITAXEL IN THE TREATMENT OF CANCER PATIENTS

Wu Hai ying,Guan Zhongzhen,He Youjian,Department of Medical Oncology,Cancer Hospital,Sun Yat sen University of Medical Sciences,Guangzhou 510060  
Objective:To evaluate the efficacy and toxicity of paclitaxel in patients with a variety of malignancies.Methods:Paclitaxel was administered as a single agent at a dose of 175 mg/m 2 or in combination chemotherapy at a dose of 135 mg/m 2 by 3 hour iv infusion every three weeks.All patients received premedication (dexamethasone,diphenhydramine,and cimetidine)to prevent hypersensitivity reactions.Results:Three hundred and thirty three patients were entered into this study.167 patients were treated with paclitaxel single agent therapy and 166 patients were treated with paclitaxel combined with cisplatin or doxorubicin or other chemotherapeutic agents.Responses were observed in patients receiving paclitaxel treatment alone,with the overall response rate for ovarian cancer being 37%,breast cancer 39%,non small cell lung cancer 31%,small cell lung cancer 40%, and nasopharyngeal cancer 67%.Responses were also achieved in patients receiving paclitaxel combination chemotherapy,with the overall response rate for ovarian cancer being 38%,breast cancer 44%,non small cell lung cancer 31%,small cell lung cancer 40%,and nasopharyngeal cancer 44%.The major toxicity associated with paclitaxel included neutropenia,myalgia and arthralgia,peripheral neuropathy,and alopecia.Conclusion:At this dose and schedule,paclitaxel is well tolerated and has notable antitumor activity.Paclitaxel may be combined with other chemotherapeutic agents for the treatment of cancer patients.
【CateGory Index】: R273.052
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