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《Chinese Journal of Integrated Traditional and Western Medicine》 1992-03
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Study of Antitumor Effect of Tripterygium wilfordii

Xu Jing-ya Yang Jun Li Le-zhen Hubei Academy of Traditional Chinese Medicine and Pharmacy,Wuhan(430073)  
A new component of antitumor action TG has been isolated from the ethyl acetated extract of Tripterygium wilfordii (besides Triptolide, Tripdiolide and Triptonide). TG was shown in this study to have obvious antitumor effects. The average life span of H_(22), S_(180), EAC and breast carcinoma-bearing mice treated wich TG ip×2 days were 100% more than those of the control mice (P0.01)TG was able to inhibit tumor growth of S_(37)-bearing mice at the dose of 150mg/kg per day, ig×3,its inhibitory rate was 42% (P0.01). TG could also inhibit squamous epithelial lung carcinoma induced by 3-methycholanthrene. The inhibitory rate was 65.13% (P0.05). TG had remarkable killing effect on human HL_(60) and Daudi cells and two direction effects on function M(?) of mouse abdominal cavity in vitro.
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