Study on Effects of Improving Memory and Inhibiting Acetylcholinesterase Activity by Invigorating-Qi and Warming-Yang Recipe
Liu Zu-yi, Yang Yun-gao, Zheng Bing Hunan Institute of TCM, Changsha (410006)
Invigorating-Qi and Warming-Yang (IQWY) had a good curative effect to some senile diseasessuch as senile dementia, senile hypomnesia etc. This experiment was designed for probing into thetherapeutical mechanism of IQWY recipe. BALB/C pure bred mice were divided into five groups.Group I was taken per os of invigorating Qi (IQ), Group Ⅱ warming Yang (WY), Group Ⅲ IQWYdrugs, Group Ⅳ was dysmnesia model, and Group Ⅴ blank control group injected with normal salineonly. All groups except Group Ⅴ were injected scopolamine (5mg/kg) intraperitoneally to inducedysmnesia model after medication. IQ drug consisted of Codonopsis pilosula, Astragalus mem-branaceus, Poria cocos, and Glycyrrhiza uralensis, WY drug of Cynomorium songoricum, Epimediumbrevicornum and Cuscuta chinensis, while IQWY recipe consisted of both IQ and WY drugs. Theresults showed that IQ, WY and IQWY had an evident antagonistic action to Scopolamine induceddysmnesia mice, and could improve their memory. The erroneous times of the animal's reaction inGroup Ⅰ, Ⅱ and Ⅲ were less than those in Group IV, P 0.05 or P 0.01. Acetylcholinesterase(AchE) activity in the mice could be inhibited by IQ, WY and IQWY also. The activity in Group Ⅰ,Ⅱ and Ⅲ was less than that in Group Ⅳ and Ⅴ, P 0.05 or P 0.01. The therapeutic mechanism ofIQWY was in connection with its effect to M-cholinergic transmitters of central nervous system.
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