Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE》 1998-01
Add to Favorite Get Latest Update

Clinical and Experimental Research of Epimedium brevicornum in Relieving Neuroendocrino-Immunological Effect Inhibited by Exogenous Glucocorticoid

Cai Dingfang, Shen Shimou, Chen Xiaohong, et al (Huashan Hospital, Shanghai Medical University, Shanghai 200040 )  
Objective: To study protective effect of Epimedium brevicornum (EB) on hypothalamus-pituitary- adrenalthymus (HPAT) axis inhibited by exogenous glucocorticoid. Methods: In clinical research, variatoin of cortisol, adrenocorticotrophin (ACTH), lymphocyte proliferative reaction were observed before and after medication in 65 patients took prednisone, and were randomly divided into Fufang prednisone group (mixture of prednisone and EB) and prednison group. An experimental model of HPAT axis inhibited by corticosterone (CORT) was established to observe the effect of EB on relevant indices of HPAT axis. Results: The level of ACTH and CORT in plasma decreased and lymphocyte proliferative reaction reduced in patients (P 0.05 ). In experimental study, monoaminic transmitters activated in hypothalamus; weight of pituitary, adrenal and thymus decreased; number of CRH positive neurons in hypothalamic paraventricular nucleus, CRH positive neurofibrilin median eminence and anterior pituitary ACTH positive secretory cells decreased; adrenal fasciculate sone and thymus cortex atrophies; NK cell cytotoxicity and the level of IL-2 and γ-IFN which were prepuced by lymphocytes reduced in CORT-rats (P 0. 05). There were significant difference between Fufang prednisone group (clinical research) or EB group (experimental research) and CORT control groups, P 0. 05. Conclusion: EB could relieve neuroendocrino-immunological effect inhibited by exogenous glucoclorticoid.
【Fund】: 卫生部科学研究基金!(No94-1-186);; 上海市科学技术基金!(No9309-7)
【CateGory Index】: R285
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 10 Hits
1 Jiang Shujun 1,Wang Guilan 1,Xu Lanzhi 2 (1 Binzhou Medical College,Binzhou 256603;2 Weifang Medical College);EFFECTS OF GLUCOCORTICOID AND EPIMEDIUM ON HYPOTHALAMUS-PITUITARY-ADRENOCORTEX AXIS[J];Journal of Binzhou Medical College;2004-02
2 JIANG Shujun SUN Jianrong Wang Tao et alDepartment of Physiology,Binzhou Medical University,Binzhou 256603;Effects of the extract of Fructus Corni on secretion of corticotrophin-releasing hormone(CRH) inthe hypothalamus of animals with kidney-yang deficiency[J];Journal of Binzhou Medical University;2008-03
3 WEI Lian bo,YE Ren gao,LUAN Tu(魏连波,等) Nanfang Hospital, First Military Medical University (Guangzhou ,510515,China);Long-term Follow-up Result of Adult Frequently Relapse Nephrotic Syndrome Treated by Combined Treatment of Traditional Chinese Medicine and Western Medicine[J];JOURNAL OF CHENGDU UNVERSITY OF TARDITIONAL CHINESE MEDICINE;2000-01
4 Zuo Zhixiong Xu Shuhuai(Department of Chinese Traditional Medicine,Dali Medical College,dali 671000);Recent Research on the Chinese Kidney Nourishing Therapy for Bronchial Asthma[J];JOURNAL OF DALI MEDICAL COLLEGE;1999-01
5 Xu Jimhua, Chen Jianfei, Ma Yaling, et al (The Affiliated Zhuhai TCM Hospital of Gangzhou University of TCM, Zhuhai 519015);Studies on the Relationship Between Chinese Traditional Medicinal Differential Symptom - complex (Zheng) Types and Pituitary - Adrenal Axis Hormone Levels in NIDDM Patients[J];Journal of Radioimmanology;2000-03
6 Kang Zefeng , Gao Jiansheng , Chao Guojun , et al. (The Ophthalmological Hospital, China Academy of Traditional Chinese Medicine,Beijing 100040);Clinical Observation of the Effects of Yiqijiedu Formula in the Treatment of Recurrent Herpes Simplex Keratitis[J];Journal of Beijing University of Traditional Chinese Medicine;2004-01
7 LUO Xiao-qun,ZHU Lu-chuan,TAO Ling-di,SU Wei,FU Hai-jun,ZHENG Zhi-zhong,CAI Ding-fang,WENG Meng-wu(De partment of Dermatology,Huashan Hospital,Fudan University,Shanghai200040,China);The clinical and laboratory research for Chinese traditional medicine in the treatment of pemphigus[J];Journal of Clinical Dermatology;2003-01
8 WEI Lian bo 1, LU Yuan yuan 2, YE Ren gao 3, LIAN Tu 2 ( 1 Internal Medicine Department of Nanfang Hospital of the First Military Medical University, Guangzhou,Guangdong, 510515,China; 2 Guangzhou Rehabilitation Center of the Disabled Associati;Clinical Observation on Integrated Treatment of Western Medicine and TCM in Adult Hormone dependent Primary Nephritic Syndrome[J];JOURNAL OF NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;2000-04
9 LU Shan-meiXU De-shengWANG Wen-jianHE Rui-jingCHEN Wei-huaVisceral Picture Research Department,Huashan Hospital,Fudan University,Shanghai;Effects of Kidney-Tonifying,Splfeen-Nourishing and Blood-Activating Methods on Sex Hormone Secretion and Immunologic Function in Postmenopausal Women[J];Shanghai Journal of Traditional Chinese Medicine;2001-12
10 Wang Ruihui,Liu Li,Li Hui (Shaanxi College of Traditional Chinese Medicine,Xianyang,Shaanxi,712083);Like Tripterygium Glucosides Animal Experimental Study on the Anti-inflammatory Effects of Chinese Herbs[J];Journal of Shaanxi College of Traditional Chinese Medicine;2004-05
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 LUO Yong1,2 NIE Jing1,3 GONG Qi-hai1,3 LU Yuan-fu1,3 WU Qin1,3 SHI Jing-shan1,3 1. Department of Pharmacology,Zunyi Medical College 2. Department of Neurology,Guizhou Aerospace Hospital 3. The Key Laboratory of Basic Pharmacology of Guizhou Province;Effects of Icariin on Intracerebral Cholinergic Nervous System in Rats of Dementia Induced by Aluminum Trichloride[J];Shanghai Journal of Traditional Chinese Medicine;2008-04
2 SHENG Rong 1, SONG Ying 1, ZHANG Yi 2 (1.The Hospital Affiliated to Chengdu University of TCM, Chengdu 610072 , China; 2.Chengdu University of TCM, Chengdu 610072, China);Determination of Icarlin in Li Shui Xiao Zhong Oral Liquid by HPLC[J];LiShiZhen Medicine and Materia Medica Research;2003-11
3 Zhao Wanjun,Xiao Luwei,Tong Peijian,et al Hangzhou Hospital of Tarditional Chinese Medicine,310006;The Prophylaxis Effect of Youguiying(YG) And Lumapian(LM) on the Steroid-induced ANFH[J];Chinese Journal of Traditional Medicial Traumatology & Orthopedics;2000-05
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Wang Jian,Hu Jianpeng ( Anhui College of TCM,Hefei 230038 );PRELIMINARY STUDY ON ANIMAL’S MODEL OF QI DEFICIENCY AND BLOOD STASIS IN ISCHEMIA STROKE[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;1999-02
2 马宗华;CURIE TEMPERATURE AND THE TEMPERATURE DEPENDENCE OF MAGNETIC PROPERTIES STUDY OF CoGa CONTAININGNANOMETERSCALE αFe/Nd2Fe14B EXCHANGECOUPLED RAREEARTH PERMANENT MAGNETS[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;1999-04
3 Hong Xingqiu, et al(Institute of Molecular Medicine, Hangzhou 310009);Experimental Study of Pinellia Tuber on Reducing Blood-Lipid[J];Journal of Zhejiang College of Tcm;1995-02
4 Ma Yiquan (The 1st Hospital in Huzhou, Huzhou 313000);The Effect of Bolus of Six Drugs Including Rehmannia on Glucorticoid Recepter (GCR) Lever in the Nephrolic Syndrome (NS) Patients' Blood[J];JOURNAL OF ZHEJIANG COLLEGE OF TCM;2000-03
5 He Seiping,Xu Xiaodong,Lou Zhengqing,et al Zhejiang College of TCM,Hangzhou(310053);Syndrome of Blood Retention and Its Animal Model Making[J];Journal of Zhejiang College of Tcm;2002-06
6 Zhou Lu, Zhang Qiaoping, Xu Xiaoping, et al Zhejiang University of TCM, Hangzhou(310053);Effect of the Sheng Jing Tang on the Ovarian Funtion and Morphology of Female Rat Anovulatory Due to Testosterone[J];Journal of Zhejiang University of Traditional Chinese Medicine;2006-06
7 Shen Y'an (Shanghai College of TCM, Shanghai);An Experimental Research on a Theory of "fright injuring kidney"[J];;1991-01
8 Xu Desheng (The Huashan Affiliated Hospital of Shanghai Medical University, Shanghai);Observation of Double Function of Preventing and Treating Asthma with Ningchuai Granule[J];China Journal of Traditional Chinese Medicine and Pharmacy;1995-05
9 Zheng Bing , et al. (Hunan Research Institute of TCM, Hunan);Effect of Drugs used to Supplement Qi and Warm Yang on the Biochemical Influence of Rat Hypothalamus[J];China Journal of Traditional Chinese Medicine and Pharmacy;1997-02
10 Wang Ziyong (Zhejiang College of Traditional Chinese Medicine, Zhe Jiang);Differentiation and Analysis on the Same Name Recipes in "Synopsis of the Golden Chamber" and "Treatise on Febrile Diseases[J];China Journal of Traditional Chinese Medicine and Pharmacy;1997-04
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Hu Suying TCM Hospital of Dongyang City, Zhejiang Province(322100);Wei Qiping Treat Pure Herpes Virus Keratitis[J];Journal of Zhejiang University of Traditional Chinese Medicine;2006-03
2 Yu Yong,Zhang Li,Cai Qianrong,et al Zhejiang Shengli Tongde Hospital,Hangzhou(310012);Revised Pinellia Combination Treat Digestive Tract Reaction from Chemical Therapy after Operation of Gastric Cancer[J];Journal of Zhejiang University of Traditional Chinese Medicine;2006-04
3 GUAN Jing, ZHOU Xiu-qing, BAN Hong-yan, ZHENG Yao. Department of Stomatology, Hebei Provincial Hospital, Shijiazhuang 050051;Effect of Chinese herbs-kidney-benefit on level of tumor necrosis factor-α in peripheral blood of rat[J];Beijing Journal of Stomatology;2005-01
4 ZHENG Yao,ZHOU Xiu-qing,BAN Hong-yan,GUAN Jing. Department of Stomatology, Hebei Provincial Peoples Hospital, Shijiazhuang 050051;Effect of kidney-invigorating mixture on periodontal pocket flora of rats[J];Beijing Journal of Stomatology;2005-02
5 ;Rational therapeutic strategies for pemphigus and prognostic analysis[J];Journal of Jilin University(Medicine Edition);2007-04
6 YANG Yu-hua12,LI Zhen2(1Shandong Center for Disease Control and Prevention,Jinan 250014,China;2 Shandong University of Traditional Chinese Medicine,Jinan 250014,China);Study on brain gene chip of mouse model with def iciency of kidney-yang syndrome[J];China Journal of Traditional Chinese Medicine and Pharmacy;2008-05
7 MAO Zhu-jun1,DONG Yin2,LUAN Jie1,XU Jun-fei1,TAO Feng1,YAO Zheng1,LU Hao1,SHEN Yuan-dong1(1Shuguang Hospital,Shanghai University of TCM,Shanghai 201203,China;2Preclinical Medical College of Shanghai University of TCM,Shanghai 201203,China);Investigation of TCM symptoms and syndrome in 180 patients with T2DM[J];China Journal of Traditional Chinese Medicine and Pharmacy;2009-08
8 JIANG Shujun SUN Jianrong Wang Tao et alDepartment of Physiology,Binzhou Medical University,Binzhou 256603;Effects of the extract of Fructus Corni on secretion of corticotrophin-releasing hormone(CRH) inthe hypothalamus of animals with kidney-yang deficiency[J];Journal of Binzhou Medical University;2008-03
9 GAO Chang, WANG Jing zhou (Department of Neurology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China);Changes of differentiation and proliferation of neural stem cells in rats treated with corticosterone[J];Acta Academiae Medicinae Militaris Tertiae;2004-17
10 CHEN Liang-zhu,YANG Li-jun,SHI Shu-ning(Guangdong Dahuanong Animal Health Products Co.,Ltd.,Xinxing,Guangdong,527400,China);Progress on Epimedium in Pharmacology[J];Progress in Veterinary Medicine;2008-S1
China Proceedings of conference Full-text Database 4 Hits
1 ;“劳倦过度、房室不节”肾阳虚模型小鼠脑基因表达谱的研究[A];[C];2008
2 Huang Zhifen, Wei Jinsong, Li Hanzhong, Zhang Zuojun, Tan Zhiqiang, Chen Chuang, Lu Yongkui Affiliated Hospital, Guangxi University of Medical Science(530021);30 Cases of Effectiveness Observation of Xiangsha Liujun Decoction Plus Ondansetron in Treating Digestive Tract Response of Chemotherapy of Cancer[A];[C];2004
3 Cai cui,Dong jing-cheng,Cui yan,Duan Xiao-hong,Liu Bao-jun,Xu Chang-qing, Cao Yu-xue and Le Jing-jing Lab of Integrative Medicine for Lung Inflammation and Cancers Huashan Hospital Fudan University;Observations of airway resistance,cytokines and HPA axis in some animal models with inflammatory airway diseases[A];[C];2009
4 YANG Wei~(1,2),SUN Yu-ming~1,ZENG Lin-ling~2,XIAO Bai-quan~2,HUANG Yuan-keng~2,ZHAO Wei-jie~(1*) (1.Dalian University of Technology,Dalian 110000,China; 2.Pharmaceutical Industrial Research Institute Guangzhou 510240,China);The effect of extraction substance of ZHIMU on the Gastrointestinal Dysfunction caused by Dexamethasone in Rats and Mice[A];[C];2009
【Secondary Citations】
Chinese Journal Full-text Database 6 Hits
1 XU Lan-Zhi;CHEN Wei-Ning (Department of Pharmacology, Weifang Medical College, Weifang 261042);Blocking effect of total flavones of epimedium on adrenergic receptor[J];CHINESE PHARMACOLOGICAL BULLETIN;1994-04
2 XIONG Yue-bin; ZHOU Chu-hua(Jiangxi Institute of Medical Sciences),Nanchang 330006;The effect of extracts from herba epimedii and semen cuscutae on thefunction of male reproduction[J];CHINESE PHARMACEUTICAL JOURNAL;1994-02
3 Niu Rui(Gansu College of Traditional Chinese Medicine, Lanzhou);Action of the Drug Herba Epimedii on the Testosterone of Mouse Plasma and Its Accessory Sexual Organ before and after Processing[J];China Journal of Chinese Materia Medica;1989-09
4 Cai Dingfang;Kojima; Satoru,Shen Ziyin et al(Insitute of Integrated Traditional and Westrnmedicine,Shanghai Medical University,Shanghai 200040);THE REGULATION OF YG ON THE HYPOTHALAMIC-PITU-ITARY-ADRENAL THYMUS AXIS OF RATS INHIBITED BY COR-TICOSTERONE[J];CHINESE JOURNAL OF IMMUNOLOGY;1994-04
5 Cai Ding fing,Shen Ziyin,Zhang Lingjuan et al.Instiute of Instute of Inegrated Tradttionaland Western Medicine,Shanghai Medical University,Shanghai 200040;THE REGULATION OF YG ON THE CELLULAR IMMUNITY ANDCYTOKINE OF RATS INHIBITED BY CORTICOSTERONE[J];CHINESE JOURNAL OF IMMUNOLOGY;1995-04
6 Shan Yuqing, et al(Institute of Medicinal Biotechnology, Beijing);Effect of Flavone Glycosides of Epimedium koreanum on Murine Fibrinolytic System and Apoplectic Mortality[J];Acta Academiae Medicinae Sinicae;1992-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved