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Clinical and Experimental Research of Epimedium brevicornum in Relieving Neuroendocrino-Immunological Effect Inhibited by Exogenous Glucocorticoid

Cai Dingfang, Shen Shimou, Chen Xiaohong, et al (Huashan Hospital, Shanghai Medical University, Shanghai 200040 )  
Objective: To study protective effect of Epimedium brevicornum (EB) on hypothalamus-pituitary- adrenalthymus (HPAT) axis inhibited by exogenous glucocorticoid. Methods: In clinical research, variatoin of cortisol, adrenocorticotrophin (ACTH), lymphocyte proliferative reaction were observed before and after medication in 65 patients took prednisone, and were randomly divided into Fufang prednisone group (mixture of prednisone and EB) and prednison group. An experimental model of HPAT axis inhibited by corticosterone (CORT) was established to observe the effect of EB on relevant indices of HPAT axis. Results: The level of ACTH and CORT in plasma decreased and lymphocyte proliferative reaction reduced in patients (P 0.05 ). In experimental study, monoaminic transmitters activated in hypothalamus; weight of pituitary, adrenal and thymus decreased; number of CRH positive neurons in hypothalamic paraventricular nucleus, CRH positive neurofibrilin median eminence and anterior pituitary ACTH positive secretory cells decreased; adrenal fasciculate sone and thymus cortex atrophies; NK cell cytotoxicity and the level of IL-2 and γ-IFN which were prepuced by lymphocytes reduced in CORT-rats (P 0. 05). There were significant difference between Fufang prednisone group (clinical research) or EB group (experimental research) and CORT control groups, P 0. 05. Conclusion: EB could relieve neuroendocrino-immunological effect inhibited by exogenous glucoclorticoid.
【Fund】: 卫生部科学研究基金!(No94-1-186);; 上海市科学技术基金!(No9309-7)
【CateGory Index】: R285
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