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《Chinese Journal of Integrated Traditional and Western Medicine》 2002-11
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Effect of Yichan Decoction on Behavior Pattern and Cerebral Black Substance Cell Morphology in Parkinson′s Disease Model Rats

YANG Ming hui, DOU Yong qi, LIU Yi Department of TCM, General Hospital of PLA, Beijing (100853)  
Objective: To explore the mechanism of therapeutic effect of Yichan Decoction (YCD) in treating Parkinson′s disease (PD). Methods: A PD model was established. A normal control group, a model group and a YCD group were set up to observe changes of rats′ behavior pattern and cell morphorlogy of cerebral black substance. Results: Compared with the model group, obviously more cells of black substance were found in the YCD group, with the neurons full in volume and clear in structure, and the intracellular Golgi complex and mitochondria close to be normal. YCD can also significantly improve the rotation behavior of the PD model rats (P0 01). Conclusion: YCD can facilitate the repair of injured cerebral black substance cells. Results of this study provide an experimental basis for clinical treatment of PD with YCD.
【Fund】: 国家自然科学基金资助课题 (No .39970 91 3)
【CateGory Index】: R285.5
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