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《Chinese Journal of Integrated Traditional and Western Medicine》 2010-11
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Protective Effect of Astragalosides on Anoxia/Reoxygenation Injury of Hippocampal Neuron

YIN Yan-yan,ZHU Fen-fang,WU Guo-cui,et al Department of Pharmacology,Anhui Medical University,Hefei(230032)  
Objective To study the effect of astragalosides(AST) on the anoxia/reoxygenation(A/R) injured neuron in rat.Methods Primary cultured rat’s hippocampal neurons were made into A/R model cells.The cell viability was detected by MTT assay and lactate dehydrogenase releasing methods;the activity of superoxide dismutase(SOD),and contents of malondialdehyde(MDA) and nitride oxide(NO) in culture supernate were detected;the apoptosis rate of hippocampal neurons after A/R was measured by flow cytometry with double-staining of hoechst33258 and AnnexinVPI;and intracellular calcium ion [Ca2+]i was observed with a cofocal laser-scanning microscope and determined by fluorescent probe Fluo-3/AM.Results AST enhanced the cell viability of neurons after A/R injury,increased SOD activity and decreased the MDA and NO contents in supernate,reduced the A/R-induced apoptosis and decreased the calcium overload in neurons.Conclusion AST has the protective effects on A/R injured neurons,the mechanism is possibly related with its anti-oxidation and calcium overload reducing actions.
【Fund】: 安徽省教育厅自然科学基金(No.KJ2008B301);; 安徽省高等学校青年教师科研资助项目(No.2008jq1059zd);; 安徽省人才开发基金资助项目(No.2007Z0301);; 安徽省自然科学基金项目(No.00144414)
【CateGory Index】: R285.5
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【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 LI Geng ICU,People′s Hospital of Qingyang Municipality,Qingyang 745000,China;Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Encephalopathy Treated with BuYang HuanWuTang as Adjuvant:A Report of 36 Cases[J];Western Journal of Traditional Chinese Medicine;2012-04
2 LUAN Zeng-qiang1,ZHAO Ping-li2,CAO Wen-fu2 1.Department of Internal Medicine,Hospital of Traditional Chinese Medicine of Neijiang,Neijiang 641000,China 2.Department of Traditional Chinese Medicine Integrated with Western Medicine,the First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China;Research Status of Astragali Radix on Nerve Cells and Nerve System Diseases[J];中草药(英文版);2012-04
3 MA Lanjun1,TIAN Zhenjun2(1.Department of Physical Education,Xian University of Architecture & Technology,Xian 710055; 2.College of Physical Education of Sport,Shaanxi Normal University,Xian 710062);Effects of acute exercise to exhaustion on BcL-2,Bax gene of rat, sheart after supplyment of astragalus polysaccharide[J];Journal of Huazhong Normal University(Natural Sciences);2012-02
4 WANG Hai-bin,DONG Wei-li,ZHANG Tie-min.SHI Jing,ZHANG Zhao (Department of Ophthalmology,Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei,China;Traditional Chinese Medicine with Boosting Qi and Nourishing Yin and Quickening the Blood and Transforming Stasis and Acupuncture in Treating Diabetic Retinopathy:A clinical report[J];Liaoning Journal of Traditional Chinese Medicine;2008-11
5 WANG Fa-wei,XU Cheng-yong,HUANG Quan-zhi,ZHANG Gang,CHENG Li-ping(Department of TCM,Chinese PLA General Hospital,Beijing 100853,China);Effect of Shenlong Jiannao Capsule on Expressions of BDNF and TrkB in Hippocampus of Cerebral Ischemia Rats[J];Journal of Liaoning University of Traditional Chinese Medicine;2012-09
6 YANG Tao1,ZHENG Qi2,FAN Yong-ping1(Corresponding Author)(1.Beijing Tiantan Hospital Affiliated to Capital Medical University,Beijing 100050,China; 2.Capital Medical University School of Traditional Chinese Medicine,Beijing 100069,China);The Research Development of Traditional Chinese Medicine on Promoting the Proliferation and Differentiation of Neural Stem Cell[J];Guiding Journal of Traditional Chinese Medicine and Pharmacy;2012-11
7 LI Hua,LIU Wang-hua,LIAO Liang-ying,et al (Department of Clinical Basic Subjects ,Hunan University of TCM ,Changsha 410208,China);Effect of Tonifying Spleen therapy on the degradation of laminin in rats with cerebral ischemia-reperfusion[J];Chinese Journal of Geriatric Heart Brain and Vessel Diseases;2010-07
8 TAO Lu-ling1,LIU Ke2(1.Henan Traditional Chinese Medicine College,Zhengzhou 450003,China;2.First Affiliated Hospital of Henan Traditional Chinese Medical College,Zhengzhou 450003,China);Experimental Research Progress on Chinese Medicine Monome Protection of Cerebral Ischemia Reperfusion Injury[J];Lishizhen Medicine and Materia Medica Research;2012-12
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Zheng Wenqiu,Zhu Min Second People Hospital of Wenzhou City,Zhejiang Province(325000);Sanqi Glucoside R1 Induce the Expression of Survivin and bcl-2 in HL-60 Cell Perishing[J];Journal of Zhejiang University of Traditional Chinese Medicine;2007-05
2 WANG Xiu-li1,CHEN Dong2,LIU Jia-mei1(1.Department of Histology and Embryology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China;2.Department of Histology and Embryology,Guangdong Medical College,Zhanjiang 524023,China);Differentiation of PC12 cells into neurons induced by NGF[J];Journal of Jilin University(Medicine Edition);2007-05
3 LI Hong,GUAN Feng-ying,LIU Ya-dong,SHI Zhuo,YANG Shi-jie(Department of Pharmacology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China);Protective effects of Flavone mixture of crataegus leave on myocardial ischemia reperfusion injury in rats[J];Journal of Jilin University(Medicine Edition);2010-04
4 CHEN Xi(Basic Theory Institute of TCM,China Academy of Chinese Medical Sciences,Beijing 100700,China);Researches on core concept of 'preventing possible disease'[J];China Journal of Traditional Chinese Medicine and Pharmacy;2009-06
5 HAN Hui,WU Li-min,WANG Han,et al(The PhD of Beijing University of TCM,Beijing 100029,china);Effects of Renshen Chuanxiongqin Injection on SOD activity,MDA concentration in serum and EAA concentration in brain tissue in Rats with Focal cerebral ischemia[J];Journal of Chengdu University of Traditional Chinese Medicine;2009-01
6 Zhao Zheng,Wu Lijun Soprts institue,Shanxi Medical University;Astragalus Extract to Rat Oxygen Free Radical Influence[J];Journal of Changzhi Medical College;2012-02
7 JI Zhi-hong,YU Xin-yu,WANG Hui,TANG Ming,LIU Bin,LIU Fei-feng,PU Zhi-yun(Laboratory of Neuroscience,Medical College,Dalian University,Dalian 116622,China);Effects of the water extract of Alpinia oxyphylla Miq.fruit on the ability of learning and memory in D-galactose induced mice[J];Journal of Northeast Normal University(Natural Science Edition);2007-02
8 Qi-Xin WANG, Ling HE, Ying JIANG, Li-Ping CHEN. Department of Neonatology, Jiangxi Children ' s Hospital, Nanchang 330006, China (Email: erwang50@263.net);Clinical Study on Panax Notoginseng Saponins in the Treatment of Neonatal Hypoxic-Is-chemic Encephalopathy[J];Chinese Journal of Contemporary Pediatrics;2003-02
9 ZHOU Jia-mao,YAN Feng-xiang,QUAN Jian-she,ZHOU Ji,LI Kui-xiang,CHEN Xiong-xin,YU Ping,NIE Lan-xiu,YIN Shi-zhu,CHEN Yi-xi,XIE Lan.Medical Department of Hunan Environment-biology college,Hengyang 421001,China;Experimental studies of Huoluojiangu capsule on anti-inflammatory efficiency[J];Journal of Chinese Physician;2006-05
10 Chi Cuiping(China Institute for Radiation Protection,Taiyuan,030006);Applications of ESR Measurement in Biomedical Field[J];Radiation Protection Bulletin;2001-05
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 DING Jin-xiang;HUANG Yun;LI Yong;CHEN Na;HAO Peng-fei;TANG Jin-tian;ZHANG Ze-sheng;College of Food Engineering and Biotechnology,Tianjin University of Science and Technology;Institute of Nuclear Energy Technology,Tsinghua University;School of Chemical and Biological Engineering,Lanzhou Jiaotong University;School of Chinese Materia Medica,Beijing University of Chinese Medicine;;Study on Extraction Technology of Antioxidant Bio-active Components from Fuzhuan Tea[J];Food Research and Development;2013-16
2 HAN Hui;WU Li-min;CHU Dan-chen;FANG Shu-zhen;YANG Wen-ming;WANG Xiao-yang;WANG Han;WANG Mei-xia;DONG Ting;HAN Ming-xiang;Encephalopathy Center,First Affiliated Hospital,Anhui University of Chinese Medicine;Workroom of State Administration for Famous Experts in Traditional Chinese Medicine,Management Bureau of Traditional Chinese Medicine,First Affiliated Hospital to Anhui University of Chinese Medicine;Medical Research Center,Anhui Provincial Hospital;;Effect of Shenxiong granules on regeneration of neural cells in hippocampus and spatial learning and memory ability in rats with cerebral ischemia[J];Tianjin Journal of Traditional Chinese Medicine;2013-11
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Yao Chenling Huang Peizhi Tong Chaoyang , et al. (Department of Emergency, Zhongshan Hospi-tal, Fudan University, Shanghai 200032);The Protective Effect of Astragale on the Culturing Neural Cells[J];Clinical Medical Journal of China;2002-02
2 Liu Wei, Cheng Yan, Wang Qian Institute of Neurology, Tianjin General Hospital, Tianjin Medical University, Tianjin 300052, China;Brain-derived Neurotraphic Factor and Cerebral Ischemic Injury[J];Cerebrovascular Diseases Foreign Medical Sciences;2004-06
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