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《Chinese Journal of Integrated Traditional and Western Medicine》 2010-11
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Protective Effect of Astragalosides on Anoxia/Reoxygenation Injury of Hippocampal Neuron

YIN Yan-yan,ZHU Fen-fang,WU Guo-cui,et al Department of Pharmacology,Anhui Medical University,Hefei(230032)  
Objective To study the effect of astragalosides(AST) on the anoxia/reoxygenation(A/R) injured neuron in rat.Methods Primary cultured rat’s hippocampal neurons were made into A/R model cells.The cell viability was detected by MTT assay and lactate dehydrogenase releasing methods;the activity of superoxide dismutase(SOD),and contents of malondialdehyde(MDA) and nitride oxide(NO) in culture supernate were detected;the apoptosis rate of hippocampal neurons after A/R was measured by flow cytometry with double-staining of hoechst33258 and AnnexinVPI;and intracellular calcium ion [Ca2+]i was observed with a cofocal laser-scanning microscope and determined by fluorescent probe Fluo-3/AM.Results AST enhanced the cell viability of neurons after A/R injury,increased SOD activity and decreased the MDA and NO contents in supernate,reduced the A/R-induced apoptosis and decreased the calcium overload in neurons.Conclusion AST has the protective effects on A/R injured neurons,the mechanism is possibly related with its anti-oxidation and calcium overload reducing actions.
【Fund】: 安徽省教育厅自然科学基金(No.KJ2008B301);; 安徽省高等学校青年教师科研资助项目(No.2008jq1059zd);; 安徽省人才开发基金资助项目(No.2007Z0301);; 安徽省自然科学基金项目(No.00144414)
【CateGory Index】: R285.5
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【Secondary References】
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1 DING Jin-xiang;HUANG Yun;LI Yong;CHEN Na;HAO Peng-fei;TANG Jin-tian;ZHANG Ze-sheng;College of Food Engineering and Biotechnology,Tianjin University of Science and Technology;Institute of Nuclear Energy Technology,Tsinghua University;School of Chemical and Biological Engineering,Lanzhou Jiaotong University;School of Chinese Materia Medica,Beijing University of Chinese Medicine;;Study on Extraction Technology of Antioxidant Bio-active Components from Fuzhuan Tea[J];Food Research and Development;2013-16
2 HAN Hui;WU Li-min;CHU Dan-chen;FANG Shu-zhen;YANG Wen-ming;WANG Xiao-yang;WANG Han;WANG Mei-xia;DONG Ting;HAN Ming-xiang;Encephalopathy Center,First Affiliated Hospital,Anhui University of Chinese Medicine;Workroom of State Administration for Famous Experts in Traditional Chinese Medicine,Management Bureau of Traditional Chinese Medicine,First Affiliated Hospital to Anhui University of Chinese Medicine;Medical Research Center,Anhui Provincial Hospital;;Effect of Shenxiong granules on regeneration of neural cells in hippocampus and spatial learning and memory ability in rats with cerebral ischemia[J];Tianjin Journal of Traditional Chinese Medicine;2013-11
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Yao Chenling Huang Peizhi Tong Chaoyang , et al. (Department of Emergency, Zhongshan Hospi-tal, Fudan University, Shanghai 200032);The Protective Effect of Astragale on the Culturing Neural Cells[J];Clinical Medical Journal of China;2002-02
2 Liu Wei, Cheng Yan, Wang Qian Institute of Neurology, Tianjin General Hospital, Tianjin Medical University, Tianjin 300052, China;Brain-derived Neurotraphic Factor and Cerebral Ischemic Injury[J];Cerebrovascular Diseases Foreign Medical Sciences;2004-06
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