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《CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE》 1999-05
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Effect of Sijunzi Decoction on Serum Soluble Intercellular Adhesive Molecule 1, Interleukin 15 and Monocyte Antibody Dependent Cell Mediated Cytotoxicity in Patients of Spleen Deficiency

Zhang Mei, Zhang Zhonghai, Xia Tian, et al Department of TCM, Xijing Hospital, the Fourth Military Medical University, Xi'an (710032)  
Objective: To study the effect of Sijunzi Decoction (SJZD) on serum soluble intercellular adhesive molecule 1 (sICAM 1), interleukin 15 (IL 15) and monocyte antibody dependent cell mediated cytotoxicity (ADCC) in patients of Spleen Deficiency. Methods: Serum sICAM 1, IL 15 and monocyte ADCC of 66 Spleen Deficiency patients were determined by enzyme linked immunosorbent assay and modified thiazole blue test. Results: Serum sICAM 1 of Spleen Deficiency patients increased, IL 15 secretion decreased and monocyte ADCC function reduced, which displayed as lowered immune function. After SJZD treatment, all the above mentioned parameters were normalized. Conclusion: SJZD could enhance immune function of organism by strengthening Spleen and tonifying Qi.
【Fund】: 国家自然科学基金
【CateGory Index】: R285.6
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