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《Chinese Journal of Evidence-Based Medicine》 2009-05
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Ambroxol Hydrochloride for Lung Protection in Perioperative Period:A Systematic Review

CHEN Yuan1,2,MA Bin1,YANG Ke-hu1,ZHANG Peng2, 1.Evidence Based Medicine of Lanzhou University,Lanzhou 730000,China; 2.Department of Cardiothoracic Surgery,Tianjin Medical University General Hospital,Tianjin 300052,China  
Objective To systematically review the efficacy of ambroxol for lung protection in perioperative period.Methods We followed the Cochrane Collaboration methodology to conduct systematic reviews.We searched relevant randomized controlled trials(RCTs)from The Cochrane Library,PubMed,Embase,CBM,CNKI and VIP. We assessed the methodological quality for each outcome by grading the quality,and used RevMan5.0.0 to perform meta-analysis.Results Eight RCTs were eligible and included 669 patients.All of these trials used randomization but the quality scales were B.Compared to the control group,the ambroxol group had a statistically significant benefit in atelectasis,pulmonary complications,cough and expectoration degree.The RR(95%CI)were 0.44(0.25,0.78),0.51(0.34, 0.75),0.39(0.16,0.94)and 0.22(0.09,0.53),respectively.The ambroxol group was also better than the control group in sputum volume,sputum characteristics,rales and pulmonary surfactant.Conclusion Ambroxol can improve respiratory system symptoms post-operatively,reduce pulmonary complications,and prevent pulmonary surfactant from decreasing during operation.Ambroxol has a satisfactory lung protective effect in the preoperative period,but we can’t define a proper dose and usage time.
【CateGory Index】: R619
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