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《Srtoke and Nervous Diseases》 2001-04
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The study on the attenuation of memory deficit by intra-venticular administration of insulin in rats following global brain ischemia

Li Bin, Zhang Xiang, Zhang Zhiwen, et al. Department of Neurosurgery, Xi Jin Hospital, Xi'an 710032  
Objective To investigate the effect of insulin directly given into the ventricle on the changes of memory of rats following global brain ischemia. Methods Fourvessel occlusion was used to establish the model of rat global brain ischemia. 1U insulin was injected into the ventricle immediately after 20min brain ischemia. 8 weeks after reperfusion, the ability of memory of rat was tested by "Y" maze, and the pathological changes in hippocampus CA 1 region was observed. Results Tested by "Y" maze, the numbers of electric shock for the criteria (9 right reactions after 10 times electric shock) in control, treated and ischemic groups were 5.6 ± 1.2 , 8.6 ± 1.3 , 19.6 ± 2.6 respectively. The counts of normal neuron in control, treated and ischemic groups were 176.5 ± 10.6 , 112.4 ± 11.7 and 10.5 ± 0.4 respectively. Conclusion Intraventricular administration of insulin following global brain ischemia can reduce death of neurons in hippocampus CA 1 region and attenute the memory deficit in rats following transient global brain ischemia.
【Fund】: 国家自然科学基金资助项目 (No .3 9970 2 66)
【CateGory Index】: R743.3
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【References】
Chinese Journal Full-text Database 3 Hits
1 ZHAO Zheng Qing 1,WANG Xiao Lin 1, TIAN Qiong 2 1Cadet Squadron 2, Cadet Brigade, 2Center of Teaching and Experiment, School of Basic Medicine, Fourth Military Medical University, Xian 710033, China;Effect of diethylstilbestrol on the ability of learning and memory of ovariectomized mice[J];Journal of The Fourth Military Medical University;2004-02
2 ZHAO Li-mei~1,HE Xiao-jing~1,LIU Yu-lan~2(1.The Second Affiliated Hospital,China Medical University,Shenyang 110004,China;2.School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China);Effects of Borneol injection on learning and memory in mice after cerebral ischemia-reperfusion injury[J];West China Journal of Pharmaceutical Sciences;2006-01
3 LI Bing,ZHANG Xiang,JIANG Xiaofan,CAO WeidongInstitute of Neurosurgery of PLA,Xijing Hospital,Fourth Military Medical University,Xi'an 710033,China;Changes of monoamine neurotransmitters in hippocampal region post global brain ischemia of the rat[J];Chinese Journal of Neurosurgical Disease Research;2006-03
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Li Bin, Zhang Xiang, Zhang Jianning, Liu Weipin, Liang Jinwen Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710033;Protective effects of insulin on neurons in the ischemic hippocampus CA1 region in rats[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1997-02
【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 LI Bin, ZHANG Xiang, ZHANG Zhi Wen, ZHANG Ge, JIANG Xiao Fan Institute of Neurosurgery of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Intraventricular injection of insulin attenuates delayed neuronal death in rat hippocampal CA1 region[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;2000-09
2 Yang Dandi; Long Dahong; Huang Wenyang;Zeng Fanbiao; Xu Mengjie; Yan Suikai(Department of Anatomy );Regeneration of Cholinergic Fibers in Hippocampal of Adult Rat After Lesion[J];ACADEMIC JOURNAL OF GUANGZHOU MEDICAL COLLEGE;1998-01
3 WEI Dao Xiang, CHEN Jun Pao, et al. Department of Neurology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282\;;Impaired effect of kainite on the learning and memory abilities of rats model and on substarce-P of them[J];Journal of Brain and Nervous Diseases;2001-05
4 Liao Min, Liu Nengbao, Zhang Minhai et al Department of Anatomy, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030;The Change of Synapsin and PSD-95 Expression in the Hippocampal Neurons of Rats with Learning and Memory Impairment by Chronic Restraint Stress[J];Acta Universitatis Medictnae Tangji;2003-04
5 LI Bing, ZHANG Xiang, ZHANG Zhi-wen, et al. ( Xijing Hospital,Fourth Military Medical University, Xi' an 710032, China);The effect of insulin on memory of rat after global brain ischemia[J];MODERN REHABILITATION;2000-07
6 LIAO Min 1,CHEN Shi-xin 2 (1.Department of Histology and Embryology,Xianning College,Xianning Hubei 437100,China; 2.Department of Biomedical Engineering,Xianning College);Change of GFAP Expression in Hippocampal Gliocytes of Rats and Impairment of Learning and Memory in Rats by Chronic Restraint Stress[J];Journal of Xianning College(Medical Sciences);2003-05
7 WEI Dao xiang , CHEN Jun pao,XU Bin,et al. Department of Neurology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282;Impaired effect of kainite on the learning and memory abilities of rats model and on the expression of acetylcholine esterase(AChE) and S~(100)β of them[J];Chinese Journal of Behavioral Medical Science;2001-01
8 LIN Yu *, HE Shunlong, CHEN Junpao,HOU Haoming, WANG Zhanjun, HUANG Jiano. *?Department of Neurology, The PLA 421st Hospital, Guangzhou 510318. China;Indomethacin protection of inflammatory damage of hippocampus induced by β-amyloid injection[J];Chinese Journal of Geriatrics;2002-02
9 CHEN Shaoyang,WANG Qiang ,ZENG Xianglong,et al Department of Anesthesiology,Xijing Hospital,Fourth Military Medical University,Xian 710033;Effect of insulin infusion on cerebral glucoese metabolism and oxygen supply consumption balance in patients undergoing brain surgery[J];CHINESE JOURNAL OF ANESTHESIOLOGY;1999-03
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 HU Zhi-yun1, WANG Hong-jin1, JIANG Chang-bin1, LEI Yang2, HAN Jie2 (1.Department of Neurology, the Second Hospital of Dalian Medical University, Dalian116027, Chi- na;2. Department of Neurology, the First Hospital of Dalian Medical University, Dalian116011, China);Expression of glutamate and nerve growth factor in hippocampus after cerebral ischemic reperfusion[J];Journal of Dalian Medical University;2005-03
2 MIAO Jian Ting, LI Zhu Yi, LIN Hong, LEI Ge Sheng, LI Hong Zeng, SU Chang Jun, ZHU Lin, YOU Guo Xiong Department of Neurology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China;Oxidative stress induced by β-amyloid peptide in pathogenesis of Alzheimer's disease in rats[J];Journal of The Fourth Military Medical University;2001-15
3 YANG Hai Yan 1, CHEN Ya Qiong 1, HUANG Yan Hong 1, XIN Xiao Yan 1, WU Shu Guang 2 1Department of Gynaecology and Obstetrics, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China, 2Institute of Materia Medica, Fir;Kidney tonifying recipes prevents bone loss in ovariectomized mice[J];Journal of The Fourth Military Medical University;2001-17
4 HE Xiao-jing~(1,2), ZHAO Li-mei~1, LIU Yu-lan~2 (1. The Second Affiliated Hospital of China Medical University, Shenyang 110004, China; 2.School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016, China);Effects of Borneol injection on experimental cerebral ischemia in mice[J];West China Journal of Pharmaceutical Sciences;2005-04
5 . Wu shan,et al.(DePtof Neurology, Affiliated Hospital,Guiyang Medical College. Guiyang (550004));Analysis on multi-factor related to intelligence impairment in ischemic stroke[J];;1996-04
6 Wang Jing;Qiu Quanqing; Jiang Minghua(Department of Pharmacology, School of Pharmacy,Shanghai Medical University,Shanghai);THE EFFECT OF -SELENOCARRAGEENAN ON SPATIAL DISCRIMINATION LEARNING IN MICE WITH EXPERIMENTAL COGNITIVE IMPAIRMENT[J];ACTA ATADEMIAE MEDICINAE SHANGHAI;1994-06
7 LI Bing, ZHANG Xiang, ZHANG Zhiwen, LIU Weiping, ZHANG Ge, JIANG XiaofanDepartment of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China;The effect of insulin on the apoptosis of neuron in hippocampal CA1 region and the change of memory of rat post global brain ischemia[J];Chinese Journal of Neurosurgical Disease Research;2003-01
8 LI Bing, ZHANG Xiang, JIANG Xiaofan, WANG Yangang, CAO Weidong Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China;Modifying the four-vessel occlusion method to establish the global brain ischemic model of rat[J];Chinese Journal of Neurosurgical Disease Research;2005-02
9 ZHANG YAN;ZHANG He-Yun;LI Wei-Ping et al(Dept of phar Anhui Medical University,Hefei 230032);Effect of An Ji Fu on increase intelligence[J];CHINESE PHARMACOLOGICAL BULLETIN;1995-03
10 Ma Liyan,et al (Institute of Medicinal Plant Development ,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing);Protective Effect of Saponins of Panax Notoginseng on Cerebral Ischemia[J];ACTA LABORATORIUM ANIMALIS SCIENTIA SINICA;1997-02
【Secondary References】
Chinese Journal Full-text Database 8 Hits
1 GE Chao-liang1,2,WANG Ning1(1.Anhui College of Traditional Chinese Medicine,Hefei,Anhui 230038,China;2.The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China);Research progress on function mechanism of inducing resuscitation drug to vascular dementia[J];Anhui Medical and Pharmaceutical Journal;2011-03
2 JIANG Yuqing,LI Wenping.Department of Urinary Surgery,The Third Hospital of Hebei Medical University,Shijiazhuang 050051,China;The establishment of stress incontinence animal model[J];Hebei Medical Journal;2009-18
3 HAN Xu,LI Qiyi,LAI Rensheng,et al.Heart Department,Jiangsu Provincial Hospital of Traditional Chinese Medicine,Jiangsu,Nanjing 210029;Effect of Tongxinluo capsule on CHD of different apolipoprotein e(ApoE) gene[J];Hebei Journal of Traditional Chinese Medicine;2010-04
4 FENG Jun-qiang Longnan Hospital of Daqing Oilfield General Hospitas,Daqing,Heiloigiong 163453,China;Study on changes of encephalofluctuograph in patients with acute lacunar infarction[J];Journal of Medical Forum;2012-06
5 HE Xiao-jing,Q Xiao-mei(Shengjing Hospital of China Medical University,Shenyang 110004,China);Anti-cerebral ischemia effects of low-molecular weight heparin[J];Practical Pharmacy and Clinical Remedies;2008-05
6 YAO Meicun1 SHAO Jianfang2 ZOU Jiali1 JIANG Xiaofei1.1 School of Pharmaceutical Sciences,Sun Yat-sen University, Guangzhou,510006,China;2 Dalian Adverse Drug Reaction Monitoring Center,116021,China.;Research Summary on the Characteristics of Borneol.[J];Proceeding of Clinical Medicine;2009-23
7 JIANG Yong,FANG Yong-Qi,ZOU Yan-Yan.Central Lab of First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,Guangdong,China;Effects of the β-asarone on learning and memory ability and SOD,GSH-Px and MDA levels in AD mice[J];Chinese Journal of Gerontology;2007-12
8 LI Hui1,GAO Gen-De2(1.Department of Rehabilitation,Second Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310005,Zhejiang,China; 2.Teaching and Research Department of Rehabilitation,Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang,China);Clinical Study of Self-made Aromatic Olfactory Agents from Traditional Chinese Medicine in Promoting Memory[J];Chinese Archives of Traditional Chinese Medicine;2011-10
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