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《Journal of Traditional Chinese Medicine》 2007-07
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Protection of Essential Oil of Fresh Ginger against Cerebral Ischemia Reperfusion Injury

WANG Jun, LIU Hui-xia, ZHANG Wei, et al.(He'nan Provincial Academy of Chinese Medicine, Zhengzhou 450004)  
Objective To study the protection of essential oil of fresh ginger against cerebral ischemical reperfusion injury (CIRI).Methods Mouse CIRI models were established by ligating bilateral common carotid artery. The activity of Na+, K+-ATPase, Ca2+-ATPase and superoxide dismutase (SOD) and content of malondialdehyde (MDA) were detected by chemical colorimetric assay.Results As compared with sham operation group, the activity of Na+, K+-ATPase and Ca2+-ATPase in model control group decreased significantly (P0.01), but there was no obvious change in activity of SOD and content of MDA. Volatile oil of fresh ginger could increase the activity of Na+, K+-ATPase, Ca2+-ATPase and SOD and decrease the content of MDA significantly (P0.05 or P0.01).Conclusion Essential oil of fresh ginger has protective effect against CIRI by enhancing the activity of ATPase and resisting oxidation.
【Fund】: 河南省属科研单位社会公益项目预研专项资金(0641130503)
【CateGory Index】: R285.5
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