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《Journal of Traditional Chinese Medicine》 2011-04
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Effects of Bushen Huoxue Granules on Level of Dopamine in Parkinson's Disease Patients

YANG Minghui,LI Min,DOU Yongqi,LIU YI(Institute of Traditional Chinese Medicine,General Hospital of Chinese PLA,Beijing 100853)  
Objective To study the effect of Bushen Huoxue Granule(Granule for reinforcing kidney and activating blood)on dopamine(DA)in Parkinson's patients.Methods In the double-blinded clinical trial,sixty patients were randomized into two groups with 30 in each.The treatment group was treated with Bushen Huoxue Granule and the control group was with placebo,twice a day.Both groups were taking western medicine as basic treatment.The observation was carried out for 3 months.The follow-up was of 6 months after the treatment cause.Using encephalofluctuography(EFG)to measure the changes of DA in both groups at baseline time,3,6 and 9 months later to evaluate the effect of Bushen Huoxue Granule.Results In the control group,DA level decreased gradually after the treatment for 9 months,but there was no statistical difference(P0.05).In the treatment group,DA level increased in the treatment observation period and follow-up with statistical difference(P0.05).Conclusion The level of DA has being reduced along with the progress of PD.Bushen Huoxue Granule can increase the level of DA in the brain of PD patients with reliable effect.
【Fund】: “十一五”国家科技支撑计划重大项目(2006BAI04A11)
【CateGory Index】: R277.7
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