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《畜牧与饲料科学(英文版)》 2009-01
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Construction of Mouse Nutritional Obesity Model

TIAN Fang,JIN Hong-xing,CHENG Wen-yu School of Chemical Engineering and Technology,Hebei University of Technology,Tianjin 300130  
[Objective] The aim of this study is to construct the model for simple obesity induced by high-fat diet,which is closest to human obesity,laying a foundation for the studies of obesity related theories. [Method] ICR and KM mice,half male and half female,were randomly divided into the high-fat diet experimental group and the normal diet control group based on body weights,and certain days later,body weight,Lee's index,wet weight of adipose tissue,quantity of adipose cell in the same visual field and blood indices were measured. [Result] All indices mentioned above of the female ICR mouse had significant statistical differences with those of the control group(P0.01 or P0.05) . [Conclusion] To construct mouse nutritional obesity model successfully,different high-fat diets are required by different lines as well as different sexes in the same line.
【Fund】: 河北省科学技术研究与发展指导计划项目“辣椒素类减肥作用物质的开发研究”(07276452)~~
【CateGory Index】: S865.13
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