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New Research Development of Penicillin Acylese's Separate and Pure and Immobilization

YANG Zheng(School of Anhui Chemical and Industry,Anqing 246005,China)  
As a key enzyme in industry,penicillin acylase(PA) is mainly obtained from Escherichia coli strain ATCC11105,Bacllus megaterium strain ATCC14945 and mutants of these two strains,an intermediate in the manufacture of β-lactam antibiotics.We review the progress on the techniques of immobilizing penicillin acylase,and discuss their characteristics in different reaction media.Furthermore,the perspectives of penicillin acylase are also presented.
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