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Synthesis of R-2-amino-3-methyl-1,1-diphenyl-1-butanol

LI Xue-chao,XU Wei-yun,ZHANG Yi(College of Chemical Engineering,Wuhan University of Technology,Wuhan 430070,China)  
R-2-amino-3-methyl-1,1-diphenyl-1-butanol is an important catalyst for synthesis of chiral intermediates.R-valine generated(R)-2-benzyloxycarbonyl-amino-3-methyl-1,1-diphenyl-1-butanol through esterification,CBZprotection.Then through 5% Pd/C catalytic hydrogenation yelid R-2-amino-3-methyl-1,1-diphenyl-1-butanol in an overall yield of 58%.
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