The effect of Zishen Yutai pill on embryo implantation and pregnancy outcome in luteal phase of cycles undergoing in vitro fertilization and embryo transfer
WU Limin;HAN hui;HU Meihong;LUAN Hongbing;LIU Yusheng;Center for reproductive medicine, Anhui provincial hospital;First affiliated hospital of Anhui traditional Chinese medicine;
Objective: To observe the effect of Zishen Yutai pill on embryo implantation and pregnancy outcome in luteal phase of cycles undergoing in vitro fertilization and embryo transfer. Methods: 580 patients who met the inclusion criteria were randomly divided into study group(n=360) and control group(n=220). The patients in control group received regular luteal support,and the patient in study group received oral Zishen Yutai pill besides regular luteal support. Results: study group vs. control group: The rate of clinical pregnancy is 58.06% vs. 47.27%(P0.05);Embryo implantation rate is 33.13% vs. 25.76%(P0.01);The rate of threatened abortion is 15.79% vs. 25.53%(P0.05);The rate of abortion is 9.09% vs. 13.46%(P0.05);The rate of take home baby is 51.7% vs. 40.45%(P0.01)。Conclusions:The using of Zishen Yutai pill in luteal phase in IVF-ET cycles increased the embryo implantatio n rate,th e rate of clinical pregnancy and the rate of take home baby,as well as decreased the rate of threatened abortion. The rate of abortion was also decreased,but there is no significant difference because of the small sample of abortion. A study with bigger sample is expected in future.