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《Anhui Agricultural Science Bulletin》 2009-15
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Effect of Curcumin on Fat Deposition and its Mechanism in Different Breeds Chickens

Hu Zhongze et al.(College of Animal Science,Anhui Science and Technology University,Fengyang 233100,China)  
AA broilers and Wan Jiang Yellow Chickens(male) were used to study the effect of curcumin on fat depsition and its mechanise.The results showed that percentage of abdominal fat weight and percentage of liver fat weight were significantly decreased by supplementation of 250 mg/kg or 350 mg/kg curcumin(P0.05).Subcutaneous fat thicknes was significantly decreased by supplementation of 350 mg/kg curcumin(P0.05).Adding 250 mg/kg or 350 mg/kg curcumin obviously enhaced the activity of hormone sensitive lipase(HSL)(P0.05)but decreased the activity of malate dehydrogenase(MDH) in abdominal fat(P0.05).Compared with the correspanding control groups,the level of PPARα mRNA was increased and the level of PPARγmRNA、MDH mRNA were reduced after adding 250 mg/kg or 350 mg/kg curcumin,but no significant difference was examined among groups.The results implied that curcumin reduce fat deposition by enhancing the expression of PPARα mRNA and by decreasing the expression of PPARγmRNA as well as MDH mRNA.
【Fund】: 安徽省自然科学基金资助项目(070411253X)
【CateGory Index】: S831
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