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《Journal of Anhui Normal University(Natural Science)》 2002-04
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POTENTIAL-MODUIATED DNA CLEAVAGE BY Cu(Ⅱ)-HISTIDINE COMPLEX

YANG Zhousheng(College of Chemistry and Material Science, Anhui Normal University, Wuhu 241000, China)   
The interaction of Cu(Ⅱ)histidine complex with DNA was studied by the cyclicvoltammetry. The peak's changes and peak's shift of complex in the presence of DNA indicated that complexes bind to DNA molecule. DNA could be efficiently cleaved by potentialmodulated complex at physiological pH and room temperature. Oxygen acts as an important role in the potentialmediated DNA cleavage. The extent of DNA cleavage was influenced by electrolysis time and potential. DNA cleavage was surpressed by .OH radical scavenger. The experiment results indicated that the mechanism of DNA cleavage by potentialmodulated Cu(Ⅱ)histidine complex mainly was caused by .OH radical generated in the reaction. It is these .OH radical that attack DNA bond and cause its break.
【CateGory Index】: O657.1
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