Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Anhui Normal University(Natural Science)》 2003-01
Add to Favorite Get Latest Update

A NEW METHED FOR SYNTHESIS OF TAZOBACTAM

HU Yue-hua 1, ZHOU Quan 1, HU Yi-ming 2 (1.Department of Chemistry, Huangshan College, Huangshan 245021,China;2.College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China)  
A new method for synthesis of tazobactam,a new β-lactamse inhibitor, was described .6-APA was converted to M 4 by new processes of esterification and oxidation,then condensated with 2-mercaptoben-zothiazole and chlorinated with HCl. After cyclization, oxidation and hydrolysis, Tazobactam was obtained. The overall yield is 17.8%.Using H 2O 2 instead of other explosive oxidant makes the process have certain advantages ,such as mild reaction, low cast and convenient aftertreatment.
【CateGory Index】: TQ465
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved