A NEW METHED FOR SYNTHESIS OF TAZOBACTAM
HU Yue-hua 1, ZHOU Quan 1, HU Yi-ming 2 (1.Department of Chemistry, Huangshan College, Huangshan 245021,China;2.College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China)
A new method for synthesis of tazobactam,a new β-lactamse inhibitor, was described .6-APA was converted to M 4 by new processes of esterification and oxidation,then condensated with 2-mercaptoben-zothiazole and chlorinated with HCl. After cyclization, oxidation and hydrolysis, Tazobactam was obtained. The overall yield is 17.8%.Using H 2O 2 instead of other explosive oxidant makes the process have certain advantages ,such as mild reaction, low cast and convenient aftertreatment.
【CateGory Index】： TQ465