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《Journal of Anhui Normal University(Natural Science)》 2010-01
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Distribution of Estrogen Receptor α in the Rat Hippocampus of Model of Chronic Unpredictable Stress Depression

LI Wei1,TANG Xiao-wei2,LIN Sheng-bin1,ZHOU Hong-ming1,LU Ya-ping1(1.College of Life Sciences,Anhui Normal University,Wuhu 241000,China; 2.Anhui College of Chinese Traditionl Medicine,Wuhu 241000,China)  
The present study aimed to observe the distribution of ERα in the rat hippocampus of control group and depressive group.The depression model of rat was established by chronic unpredictable mild stress and separation.Observing the behavior of the depressive rats by the open-field test,using immunohistochemistry to observe ERα-immunoreactive neurons of the hippocampus.The results indicated,compared with the control,the frequency of crossing,rearing and grooming decreased significantly(P0.01),the increase of body weight and consumption of saccharobiose declined(P0.01).In the control group and depressive group,the ERα-immunoreactive neurons are mainly distributed in pyramidal cell layer and temporal cell layer of the hippocampus.Compared with the control,the number of ERα-immunoreactive neurons and staining intensity were reduced and declined in the hippocampus of depressive group.In the control group,ERα located mainly in the nucleus,cytoplast and/or neurite of the neurons,while in the depressive group ERα located mostly in the cytoplast and neurite,and seldom in the nucleus.The mechanism of the default or weaken functions of estrogen may be that estrogen lowered the ability of neuroprotection by nuclear ERα signaling during the stress induced depression.
【Fund】: 国家自然科学基金(30470537);; 生物环境与生态安全安徽省高校省级重点实验室基金;; 安徽师范大学生物大分子进化重点实验室开放基金
【CateGory Index】: R749.4
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