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《Journal of Anhui Normal University(Natural Science)》 2011-06
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Effect of Synaptophysin on Transmembmne Voltage of Sinoatrail Node

MA Wen-yang1,ZHANG Ji-qian1,2,WANG Meng1,ZHANG Heng-gui2)(1.College of Physics and Electrical Information,Anhui Normal University,Wuhu 241000,China;2.Biological Physics Group,School of Physics &Astronomy,The University of Manchester,Manchester,M13 9PL,UK)  
By using an experiment model of SA node cell in the rabbit heart,which proposed by Zhang et al,the effect of the content of synaptophysin in SA node on transmembmne voltage of SA node is investigated by computer simulation.The results show,on one hand,using this model,it can be reproduced the phenomenon of abnormal rhythm in heart with physiological defect,and these results are consistent with those clinical phenomena,such as abnormal pacemaking or even sudden cardiac death,which induced by reduction of synapsin content in sinus node for elders or chronic alcoholics heart.On the other hand,the decrease of synapsin may influence the SAN in two aspects mainly,weakening the conductive activity of calcium ion channel,and reducing the secretion of acetylcholine,and these two effects directly reduce SAN 's oscillation capability.These results will help to reveal the internal connection,between the decrease of synaptophysin in the sinoatrial node and abnormal pacemaking in complex cardiac system.And provide a theoretical guidance for the clinical diagnosis of angiocardiopathy,such as,sudden cardiac death and sick sinus syndrome.
【Fund】: 国家自然科学基金理论物理专款项目(11047017);; 安徽省自然科学基金(2009KJ099B);; 安徽师范大学创新团队科研基金;; 威康信托基金Wellcome Trust(081808/Z/06/Z);; 英国生物工艺科学研究基金BBSRC(BBS/B1678X)
【CateGory Index】: Q42
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