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Characterization of diuretic effect and nephrotoxicity of the Aristolochia fangchi total extract in comparison with Stephania tetrandra

ZHANG Liang1,2,JIANG Zhen-zhou2,BIAN Yong1,LI Ji2,YUAN Dong-ping1,LONG Jun1 FANG Tai-hui1 (1.Department of Pharmacology,Nanjing University of Chinese Medicine,Nanjing 210046;2.New Drug Screening Center,China Pharmaceutical University,Nanjing 210009)  
Aim To investigate the effect of total extract of Aristolochia fangchi(AFt) and Stephania tetrandra(STt) on diuresis and renal toxicity respectively,and compare the differences of effects between the two total extract with the effective dose.Methods The effect of AFt and STt on urinary production of normal rats and electrolytes in the urine,and the changes related to renal function were determined with weighing and metabolic cage.Meanwhile,the diuretic action and nephrotoxicity induced between the two Chinese herbs were compared.Results At the 3 d and 5 d after administration of AFt and STt respectively,the total urinary production of normal rats in the high and middle groups of AFt were significantly increased during 0~2 h and at 24 h compared with the control group(P0.05,P0.01);the differences of the concentrations of Na+、K+、Cl-in the rats urine and Uosm between the total groups in the AFt and STt and control group were not obvious;the BUN in the total groups of the AFt were increased;the CR in the urine in the middle and low groups in the AFt were increased;the express of β2-microglobulin in the urine were raised in the high and middle groups in the AFt(P0.05).Conclusions The urinary production induced in the unit time and total urinary volume in the each groups of the AFt were slightly higher than the each groups of the STt,which were not showed the statistically significance.The results indicated that renal toxicity can be induced by AFt with the effective dose,which is in relationship with pathological changes occurring in the proximal convoluted tubule,while the obvious renal injury were not determined in the STt with the same doses.
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